妄想性与非妄想性忧郁症患者对可乐定的激素反应及尿中3-甲氧基-4-羟基苯乙二醇水平：一项安慰剂对照研究

Hormonal responses to clonidine and urinary MHPG in delusional and nondelusional melancholic patients: a placebo-controlled study.

作者信息

Lykouras L, Markianos M, Hatzimanolis J, Malliaras D, Stefanis C

机构信息

Department of Psychiatry, University of Athens, Eginition Hospital, Greece.

出版信息

Eur Arch Psychiatry Clin Neurosci. 1991;241(2):77-81. doi: 10.1007/BF02191144.

DOI:10.1007/BF02191144

PMID:1657199

Abstract

The growth hormone (GH) and cortisol responses to intravenous clonidine (0.15 mg) treatment of 25 melancholic patients, 12 with and 13 without delusions, were studied with placebo control. The baseline concentrations of the main noradrenaline metabolite, 3-methoxy-4-hydroxyphenylglycol (MHPG) were also estimated in urine. Cortisol plasma levels decreased significantly and equally after both placebo and clonidine. Baseline cortisol levels correlated positively with urinary MHPG. Clonidine did not increase GH levels significantly over time compared with placebo. Delusional melancholic patients tended to have smaller GH responses to clonidine than nondelusionals (F = 2.18, P = 0.06). There were no differences in GH response to clonidine between high and low MHPG excretors.

摘要

对25例忧郁症患者（其中12例有妄想，13例无妄想）进行静脉注射可乐定（0.15毫克）治疗，并设置安慰剂对照，研究生长激素（GH）和皮质醇的反应。同时还测定了尿液中主要去甲肾上腺素代谢产物3-甲氧基-4-羟基苯乙二醇（MHPG）的基线浓度。安慰剂和可乐定治疗后，血浆皮质醇水平均显著且同等程度下降。基线皮质醇水平与尿MHPG呈正相关。与安慰剂相比，可乐定未随时间显著提高GH水平。有妄想的忧郁症患者对可乐定的GH反应往往比无妄想者小（F = 2.18，P = 0.06）。高MHPG排泄者和低MHPG排泄者对可乐定的GH反应无差异。