Department of Reproductive Physiology, Zhejiang Academy of Medical Sciences, Hangzhou, Zhejiang, China.
The Mary M. Woldford Laboratory for Male Contraceptive Research, Center for Biomedical Research, Population Council, New York, New York, USA.
Reproduction. 2019 Mar;157(3):R85-R94. doi: 10.1530/REP-18-0440.
SRC family kinases (SFKs) are known regulators of multiple cellular events, including cell movement, differentiation, proliferation, survival and apoptosis. SFKs are expressed virtually by all mammalian cells. They are non-receptor protein kinases that phosphorylate a variety of cellular proteins on tyrosine, leading to the activation of protein targets in response to environmental stimuli. Among SFKs, SRC, YES and FYN are the ubiquitously expressed and best studied members. In fact, SRC, the prototypical SFK, was the first tyrosine kinase identified in mammalian cells. Studies have shown that SFKs are regulators of cell junctions, and function in endocytosis and membrane trafficking to regulate junction restructuring events. Herein, we briefly summarize the recent findings in the field regarding the role of SFKs in the testis in regulating spermatogenesis, particularly in Sertoli-Sertoli and Sertoli-germ cell adhesion. While it is almost 50 years since the identification of the oncogene v-Src encoded by Rous sarcoma transforming virus, the understanding of SFK involvement during spermatogenesis in the testis remains far behind that in other epithelia and tissues. The goal of this review is to bridge this gap.
Src 家族激酶（SFKs）是多种细胞事件的已知调节剂，包括细胞运动、分化、增殖、存活和凋亡。SFKs 几乎在所有哺乳动物细胞中都有表达。它们是非受体蛋白激酶，可在酪氨酸上磷酸化多种细胞蛋白，从而响应环境刺激激活蛋白靶标。在 SFKs 中，Src、YES 和 FYN 是广泛表达和研究最好的成员。事实上，Src，典型的 SFK，是在哺乳动物细胞中鉴定的第一个酪氨酸激酶。研究表明，SFKs 是细胞连接的调节剂，在胞吞作用和膜运输中起作用，以调节连接重构建事件。在此，我们简要总结了该领域最近的发现，即 SFKs 在睾丸中调节精子发生中的作用，特别是在支持细胞-支持细胞和支持细胞-生殖细胞黏附中的作用。虽然自 Rous 肉瘤转化病毒编码的致癌基因 v-Src 被鉴定以来已经过去了近 50 年，但对 SFK 在睾丸精子发生中的参与的理解仍然远远落后于其他上皮组织和组织。本综述的目的是弥合这一差距。
