Institute for Reproductive Health, Hangzhou Medical College (Zhejiang Academy of Medical Sciences), Hangzhou, Zhejiang, China.
Institute of Occupation Diseases, Hangzhou Medical College (Zhejiang Academy of Medical Sciences), Hangzhou, Zhejiang, China.
Adv Exp Med Biol. 2021;1288:1-20. doi: 10.1007/978-3-030-77779-1_1.
Non-receptor tyrosine kinases (NRTKs) are implicated in various biological processes including cell proliferation, differentiation, survival, and apoptosis, as well as cell adhesion and movement. NRTKs are expressed in all mammals and in different cell types, with extraordinarily high expression in the testis. Their association with the plasma membrane and dynamic subcellular localization are crucial parameters in their activation and function. Many NRTKs are found in endosomal protein trafficking pathways, which suggests a novel mechanism to regulate the timely junction restructuring in the mammalian testis to facilitate spermiation and germ cell transport across the seminiferous epithelium.
非受体酪氨酸激酶（NRTKs）参与多种生物学过程，包括细胞增殖、分化、存活和凋亡，以及细胞黏附和运动。NRTKs在所有哺乳动物和不同的细胞类型中表达，在睾丸中表达水平极高。它们与质膜的结合和动态的亚细胞定位是其激活和功能的关键参数。许多 NRTKs 存在于内体蛋白运输途径中，这提示了一种新的机制，可以调节哺乳动物睾丸中适时的连接重构建，以促进精子发生和精母细胞穿过生精上皮的运输。
