Department of Cardiology, The First College of Clinical Medical Science, China Three Gorges University, Yichang 443000, China.
Institute of Cardiovascular Diseases, China Three Gorges University, Yichang 443000, China.
Int J Med Sci. 2021 Jan 14;18(5):1216-1224. doi: 10.7150/ijms.49241. eCollection 2021.
The Src-family protein tyrosine kinases (SFKs), a subfamily of non-receptor tyrosine kinases, are ubiquitously expressed in various cell types. Numerous studies have suggested that SFKs are related to signal transduction in major cardiac physiological and pathological processes, it is the activity of SFKs that is connected with the maintenance of cardiovascular homeostasis. Upon stimulation of various injury factors or stress, the phosphorylation state of SFKs is changed, which has been found to modulate different cardiac pathological conditions, such as hypertension, coronary heart disease, ischemic heart disease, myocardial ischemia-reperfusion injury, arrhythmia and cardiomyopathy via regulating cell growth, differentiation, movement and function, electrophysiologic signals. This review summarizes the basic information about SFKs, updates its role in the different processes underlying the development of multiple cardiovascular diseases (CVDs), and highlights their potential role as disease biomarkers and therapeutic targets, which would help understand the pathophysiology of CVDs and promote the further potential clinical adhibition.
Src 家族蛋白酪氨酸激酶（SFKs）是一种非受体酪氨酸激酶亚家族，在各种细胞类型中广泛表达。大量研究表明 SFKs 与心脏主要生理和病理过程中的信号转导有关，SFKs 的活性与心血管稳态的维持有关。在各种损伤因子或应激的刺激下，SFKs 的磷酸化状态发生改变，通过调节细胞生长、分化、运动和功能、电生理信号，调节不同的心脏病理状态，如高血压、冠心病、缺血性心脏病、心肌缺血再灌注损伤、心律失常和心肌病。本综述总结了 SFKs 的基本信息，更新了其在多种心血管疾病（CVDs）发展过程中不同阶段的作用，并强调了它们作为疾病生物标志物和治疗靶点的潜在作用，这将有助于了解 CVDs 的病理生理学，并促进进一步的潜在临床应用。
