超越骨骼：脂肪组织中的骨形态发生蛋白信号转导。
Beyond the bone: Bone morphogenetic protein signaling in adipose tissue.
机构信息
Division of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, California, United States.
Molecular Biology Institute, UCLA, Los Angeles, California, United States.
出版信息
Obes Rev. 2019 May;20(5):648-658. doi: 10.1111/obr.12822. Epub 2019 Jan 4.
The bone morphogenetic proteins (BMPs) belong to the same superfamily as related to transforming growth factor β (TGFβ), growth and differentiation factors (GDFs), and activins. They were initially described as inducers of bone formation but are now known to be involved in morphogenetic activities and cell differentiation throughout the body, including the development of adipose tissue and adipogenic differentiation. BMP4 and BMP7 are the most studied BMPs in adipose tissue, with major roles in white adipogenesis and brown adipogenesis, respectively, but other BMPs such as BMP2, BMP6, and BMP8b as well as some inhibitors and modulators have been shown to also affect adipogenesis. It has become ever more important to understand adipose regulation, including the BMP pathways, in light of the strong links between obesity and metabolic and cardiovascular disease. In this review, we summarize the available information on BMP signaling in adipose tissue using preferentially articles that have appeared in the last decade, which together demonstrate the importance of BMP signaling in adipose biology.
骨形态发生蛋白（BMPs）属于转化生长因子 β（TGFβ）、生长分化因子（GDFs）和激活素的超家族。最初被描述为骨形成诱导剂，但现在已知它们参与全身形态发生活动和细胞分化，包括脂肪组织的发育和脂肪生成分化。BMP4 和 BMP7 是脂肪组织中研究最多的 BMPs，分别在白色脂肪生成和棕色脂肪生成中起主要作用，但其他 BMPs（如 BMP2、BMP6 和 BMP8b）以及一些抑制剂和调节剂也被证明会影响脂肪生成。鉴于肥胖与代谢和心血管疾病之间的紧密联系，了解脂肪调节，包括 BMP 途径，变得越来越重要。在这篇综述中，我们使用最近十年发表的文章，总结了有关脂肪组织中 BMP 信号的现有信息，这些文章共同证明了 BMP 信号在脂肪生物学中的重要性。
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