Department of Clinical Immunology, Hôpital Saint-Louis, Assistance Publique Hôpitaux de Paris (APHP), Paris, France.
National Reference Center for Castleman Disease (CRMdC), Paris, France.
Blood. 2019 Mar 14;133(11):1186-1190. doi: 10.1182/blood-2018-11-852442. Epub 2019 Jan 4.
Kaposi sarcoma-associated herpesvirus/human herpesvirus 8 is associated with multicentric Castleman disease (MCD) and primary effusion lymphoma (PEL). In MCD, infected B cells, although polyclonal, express a monotypic immunoglobulin Mλ phenotype, probably through editing toward λ light chain in mature B cells. They are considered to originate from pre-germinal center (GC) naive B cells. Both viral and human interleukin-6 contribute to the plasmacytic differentiation of these cells, and viral replication can be observed in some infected cells. PEL cells are clonal B cells considered as GC/post-GC B cells. One can also hypothesize that they originate from the same infected naive B cells and that additional factors could be responsible for their peculiar phenotype.
卡波西肉瘤相关疱疹病毒/人类疱疹病毒 8 与多中心 Castleman 病（MCD）和原发性渗出性淋巴瘤（PEL）有关。在 MCD 中，受感染的 B 细胞虽然是多克隆的，但表达单型免疫球蛋白 Mλ 表型，可能是通过成熟 B 细胞中 λ 轻链的编辑。它们被认为起源于生发中心（GC）前的幼稚 B 细胞。病毒和人类白细胞介素-6 都有助于这些细胞的浆细胞分化，并且可以在一些受感染的细胞中观察到病毒复制。PEL 细胞是克隆 B 细胞，被认为是 GC/后 GC B 细胞。人们还可以假设它们起源于相同的受感染的幼稚 B 细胞，并且可能有其他因素导致它们的特殊表型。
