Lyu Qing-Shan, Huang Yu-Qing
Department of Cardiology, the Central Hospital of Yongzhou, Yongzhou, Hunan, China.
Hypertension Research Laboratory of Guangdong, Cardiovascular Institute, Guangzhou, China
Ann Clin Lab Sci. 2018 Nov;48(6):757-763.
It has been found that serum total bilirubin has a vital role in anti-inflammatory and antioxidant progress. Prehypertension, the intermediate stage between normal blood pressure and hypertension, is linked with subclinical atherosclerosis and target-organ damage.
This study was designed to evaluate the relationship between total bilirubin and carotid intima-media thickness (cIMT), a marker of subclinical atherosclerosis, in patients with prehypertension.
We consecutively enrolled 219 patients with prehypertension. All the participants were divided into two groups according to cIMT values (<0.9 vs. ≥0.9 mm). We found that the increased cIMT group has higher systolic blood pressure, triglyceride and C- reactive protein, but lower total bilirubin compared to the normal cIMT group. The cIMT was negatively correlated with total bilirubin. Multivariate regression analyses revealed total bilirubin was an independent factor for subclinical atherosclerosis.
This study demonstrated that serum total bilirubin was inversely related with cIMT, and was an independent predictor of subclinical atherosclerosis in patients with prehypertension.
研究发现血清总胆红素在抗炎和抗氧化过程中起着至关重要的作用。高血压前期是正常血压和高血压之间的中间阶段，与亚临床动脉粥样硬化和靶器官损害有关。
本研究旨在评估高血压前期患者总胆红素与亚临床动脉粥样硬化标志物颈动脉内膜中层厚度（cIMT）之间的关系。
我们连续纳入了219例高血压前期患者。所有参与者根据cIMT值（<0.9 vs.≥0.9 mm）分为两组。我们发现，与正常cIMT组相比，cIMT增加组的收缩压、甘油三酯和C反应蛋白更高，但总胆红素更低。cIMT与总胆红素呈负相关。多变量回归分析显示总胆红素是亚临床动脉粥样硬化的独立因素。
本研究表明，血清总胆红素与cIMT呈负相关，是高血压前期患者亚临床动脉粥样硬化的独立预测因子。
