Department of Cardiology, Gulhane Medical Academy, Ankara, Turkey.
Department of Cardiology, Beytepe Hospital, Ankara, Turkey.
Angiology. 2020 May;71(5):425-430. doi: 10.1177/0003319712473796. Epub 2013 Jan 27.
Atherosclerosis plays an important role in the etiopathogenesis of coronary artery ectasia (CAE). The relationship between total bilirubin (TBil) and carotid intima media thickness (cIMT) in patients with CAE has not been fully investigated. Hence, we evaluated the relationship between TBil levels and cIMT in 142 consecutive eligible patients with CAE, newly diagnosed coronary artery disease (CAD), and normal coronary arteries. There were no significant differences in TBil ( = .772) and cIMT ( = .791) between the CAE and CAD groups. Bilirubin levels were significantly lower in both CAE and CAD groups compared to the controls ( < .01). The cIMT was significantly higher in both CAE and CAD groups compared to control participants ( < .01). A negative correlation between cIMT and TBil was found in all the groups ( < .01, = .354). We show for the first time that patients with CAE and CAD have lower TBil and greater cIMT compared to controls with normal coronary angiograms.
动脉粥样硬化在冠状动脉扩张症（CAE）的病因学中起着重要作用。总胆红素（TBil）与 CAE 患者颈动脉内膜中层厚度（cIMT）之间的关系尚未得到充分研究。因此，我们评估了 142 例连续符合条件的 CAE、新发冠心病（CAD）和正常冠状动脉患者的 TBil 水平与 cIMT 之间的关系。CAE 组和 CAD 组之间的 TBil（ =.772）和 cIMT（ =.791）无显著差异。与对照组相比，CAE 组和 CAD 组的胆红素水平均显著降低（ <.01）。与对照组相比，CAE 组和 CAD 组的 cIMT 均显著升高（ <.01）。所有组均发现 cIMT 与 TBil 呈负相关（ <.01， =.354）。我们首次表明，与冠状动脉造影正常的对照组相比，CAE 和 CAD 患者的 TBil 水平较低，cIMT 较高。
