Owen J H, Laschinger J, Bridwell K, Shimon S, Nielsen C, Dunlap J, Kain C
Washington University School of Medicine, St. Louis, Missouri.
Spine (Phila Pa 1976). 1988 Oct;13(10):1111-8. doi: 10.1097/00007632-198810000-00010.
The purpose of this study was to report the effects of spinal cord compression, ischemia, and distraction on clinical status, and somatosensory (SEP) and neurogenic-motor evoked potentials (NMEPs) in animals. The authors also reported their clinical experience with NMEPs elicited from humans undergoing surgery for spinal deformities. Results from the animal studies indicate that NMEPs are more sensitive and specific to the effects from spinal cord compression, ischemia, and distraction than SEPs. In every situation, NMEPs always correlated with the animal's post-surgical clinical status, while SEPs demonstrated an unacceptable false positive and false negative rate. In the 111 clinical cases in which NMEPs were administered, reliable NMEPs were easily elicited in more than 90% of the cases. In the remaining cases, no reliable NMEPs could be recorded because of procedural errors, which have been resolved. The results from this study suggest that the use of NMEPs should be considered as an adjunct to SEPs when monitoring spinal cord function during surgery.
本研究的目的是报告脊髓压迫、缺血和牵张对动物临床状态、体感诱发电位（SEP）和神经源性运动诱发电位（NMEP）的影响。作者还报告了他们对接受脊柱畸形手术的人类进行NMEP检测的临床经验。动物研究结果表明，与SEP相比，NMEP对脊髓压迫、缺血和牵张的影响更敏感、更具特异性。在每种情况下，NMEP始终与动物术后的临床状态相关，而SEP则显示出不可接受的假阳性和假阴性率。在111例进行NMEP检测的临床病例中，超过90%的病例能够轻松引出可靠的NMEP。在其余病例中，由于操作失误无法记录到可靠的NMEP，但这些问题已得到解决。本研究结果表明，在手术中监测脊髓功能时，应考虑将NMEP作为SEP的辅助手段。
