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脊柱侧弯矫正手术中脊髓损伤的生物力学分析

Biomechanical analysis of spinal cord injury during scoliosis correction surgery.

作者信息

Wang Haimei, Zhang Chunyu, Wang Yongqiang, Zeng Yan, Chen Songhao, Su Xingyu, Li Weishi, Yu Miao, Chen Duanduan

机构信息

School of Medical Technology, Beijing Institute of Technology, Beijing, China.

Department of Orthopaedics, Peking University Third Hospital, Beijing, China.

出版信息

Front Bioeng Biotechnol. 2024 Jul 2;12:1399691. doi: 10.3389/fbioe.2024.1399691. eCollection 2024.

Abstract

Surgical correction is a common treatment for severe scoliosis. Due to the significant spinal deformation that occurs with this condition, spinal cord injuries during corrective surgery can occur, sometimes leading to paralysis. Such events are associated with biomechanical changes in the spinal cord during surgery, however, their underlying mechanisms are not well understood. Six patient-specific cases of scoliosis either with or without spinal complications were examined. Finite element analyses (FEA) were performed to assess the dynamic changes and stress distribution of spinal cords after surgical correction. The FEA method is a numerical technique that simplifies problem solving by replacing complex problem solving with simplified numerical computations. In four patients with poor prognosis, there was a concentration of stress in the spinal cord. The predicted spinal cord injury areas in this study were consistent with the clinical manifestations of the patients. In two patients with good prognosis, the stress distribution in the spinal cord models was uniform, and they showed no abnormal clinical manifestations postoperatively. This study identified a potential biomechanical mechanism of spinal cord injury caused by surgical correction of scoliosis. Numerical prediction of postoperative spinal cord stress distribution might improve surgical planning and avoid complications.

摘要

手术矫正是重度脊柱侧弯的常见治疗方法。由于这种病症会出现明显的脊柱变形,矫正手术期间可能会发生脊髓损伤,有时会导致瘫痪。然而,此类事件与手术期间脊髓的生物力学变化有关,但其潜在机制尚未得到充分理解。研究了6例有或无脊柱并发症的脊柱侧弯患者特异性病例。进行了有限元分析(FEA)以评估手术矫正后脊髓的动态变化和应力分布。有限元分析方法是一种数值技术,通过用简化的数值计算代替复杂的问题求解来简化问题解决过程。在4例预后不良的患者中,脊髓存在应力集中。本研究预测的脊髓损伤区域与患者的临床表现一致。在2例预后良好的患者中,脊髓模型中的应力分布均匀,术后未出现异常临床表现。本研究确定了脊柱侧弯手术矫正导致脊髓损伤的潜在生物力学机制。术后脊髓应力分布的数值预测可能会改善手术规划并避免并发症。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f793/11249739/20576acdd951/fbioe-12-1399691-g001.jpg

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