疫苗的稳定性。

Stability of Vaccines.

机构信息

Department of Pharmaceutics and Drug Delivery, The University of Mississippi, University, MS, 38677, USA.

出版信息

AAPS PharmSciTech. 2019 Jan 4;20(2):42. doi: 10.1208/s12249-018-1254-2.

Abstract

Vaccines are considered the most economical and effective preventive measure against most deadly infectious diseases. Vaccines help protect around three million lives every year, but hundreds of thousands of lives are lost due to the instability of vaccines. This review discusses the various types of instability observed, while manufacturing, storing, and distributing vaccines. It describes the specific stability problems associated with each type of vaccine. This review also discusses the various measures adopted to overcome these instability problems. Vaccines are classified based on their components, and this review discusses how these preventive measures relate to each type of vaccine. This review also includes certain case studies that illustrate various approaches to improve vaccine stability. Last, this review provides insight on prospective methods for developing more stable vaccines.

摘要

疫苗被认为是预防大多数致命传染病最经济、最有效的手段。疫苗每年帮助保护约 300 万人的生命，但由于疫苗的不稳定性，仍有数十万人失去生命。本综述讨论了在制造、储存和分发疫苗过程中观察到的各种类型的不稳定性。它描述了与每种类型疫苗相关的特定稳定性问题。本综述还讨论了为克服这些不稳定性问题而采取的各种措施。疫苗根据其成分进行分类，本综述讨论了这些预防措施与每种类型疫苗的关系。本综述还包括一些案例研究，说明了改善疫苗稳定性的各种方法。最后，本综述提供了关于开发更稳定疫苗的前瞻性方法的见解。