Elhassan M Mohammed Ali, Mohamedani A Abdalla, Osman H Hussein Mohammed, Yousif N Osman, Elhaj N Mohamed, Qaddoumi I
Department of Oncology, National Cancer Institute, University of Gezira, PO Box 20, Wad Madani, Sudan.
Department of Pathology, Faculty of Medicine, University of Gezira, Wad Madani, Sudan.
Childs Nerv Syst. 2019 Mar;35(3):437-444. doi: 10.1007/s00381-018-04032-9. Epub 2019 Jan 4.
Studies of epidemiology, treatment modalities, and outcomes of childhood central nervous system (CNS) tumors in Sudan are scarce. To address this shortcoming, we evaluated baseline information about the epidemiology, treatment types, and outcomes of childhood CNS tumors at the National Cancer Institute, University of Gezira (NCI-UG) in Wad Madani, Sudan.
We performed a retrospective health facility-based study of children with CNS tumors who were treated at the NCI-UG from January 2000 to December 2015.
A total of 62 (5.4% of all childhood cancers) pediatric patients with CNS tumors were identified over the study period. Tumors were more common among male children and involved the infratentorial compartment in 58% of cases. The median age at diagnosis was 9 years (range, 2-14 years). Approximately 60% (n = 37) of the study population had histology-determined diagnoses. Astrocytomas and medulloblastomas were the most common tumors in these cases. The mean time to diagnosis was 6 months (SD, 9). During the study period, the number of children with CNS tumors who were referred for treatment at the NCI-UG increased every year. Of the 37 patients who received surgical interventions, 8 received gross total resections, 20 received partial resections, and 24 received postoperative radiotherapy. The treatment abandonment rate was 11%. The 2-year and 5-year survival rates were 33% and 13%, respectively.
Our findings reveal a high incidence of poor outcomes for patients with CNS tumors in Sudan, which is most likely due to many distinct factors.
苏丹关于儿童中枢神经系统（CNS）肿瘤的流行病学、治疗方式及治疗结果的研究较少。为弥补这一不足，我们评估了苏丹瓦德迈达尼杰济拉大学国家癌症研究所（NCI - UG）儿童CNS肿瘤的流行病学、治疗类型及治疗结果的基线信息。
我们对2000年1月至2015年12月在NCI - UG接受治疗的CNS肿瘤患儿进行了一项基于医疗机构的回顾性研究。
在研究期间共确定了62例（占所有儿童癌症病例的5.4%）患有CNS肿瘤的儿科患者。肿瘤在男童中更为常见，58%的病例累及幕下腔室。诊断时的中位年龄为9岁（范围2 - 14岁）。约60%（n = 37）的研究人群有组织学确诊。星形细胞瘤和髓母细胞瘤是这些病例中最常见的肿瘤。平均诊断时间为6个月（标准差9）。在研究期间，转诊至NCI - UG接受治疗的CNS肿瘤患儿数量逐年增加。在37例接受手术干预的患者中，8例接受了全切，20例接受了部分切除，24例接受了术后放疗。治疗放弃率为11%。2年和5年生存率分别为33%和13%。
我们的研究结果显示苏丹CNS肿瘤患者的不良结局发生率较高，这很可能是由多种不同因素导致的。
