Diamantis Alexandros, Bouliaris Konstantinos, Christodoulidis Grigorios, Vasdeki Dionysia, Perivoliotis Konstantinos, Tepetes Konstantinos
Department of General Surgery, University Hospital of Larissa, Mezourlo, Larissa, Thessaly, 41110, Greece.
J BUON. 2018 Nov-Dec;23(6):1573-1579.
Gastrointestinal stromal tumors (GISTs) are the most frequent neoplasms of mesenchymal origin affecting the gastrointestinal tract. GISTs quite frequently co-exist with other primary tumors in up to 33% of the cases. Such occurrence has been mainly described in the literature in the form of case reports and rarely of case series which hasn't been sufficient to prove if there is any association between these two entities.
We conducted a review of the current literature regarding the synchronous occurrence of GISTs and other intra-abdominal malignancies. An electronic search of the literature was undertaken using MEDLINE (database provider PubMed). A primary selection of relevant studies was based on the title and abstract, whereas a secondary selection was performed according to the full text of publications.
Ten retrospective case series were considered and overall 1108 GISTs patients were included. Synchronous intra-abdominal malignancies were found in 18% of all GISTs patients studied. The mean age was 70,5 years, affecting more the male gender (65%). The mean size of the concurrent GISTs were 18mm while the most common GIST-associated malignancy were gastric adenocarcinomas.
The synchronous occurrence of GISTs and other intra-abdominal primary tumors is more common that it has been considered and while it is not yet clear if there is a causal association for the concomitant occurrence of GIST with other malignancies a closer surveillance of GIST patients is needed due to their proved increased prevalence of a second primary tumor especially during the first year after diagnosis.
胃肠道间质瘤（GISTs）是影响胃肠道的最常见的间充质来源肿瘤。在高达33%的病例中，GISTs常与其他原发性肿瘤共存。这种情况在文献中主要以病例报告的形式描述，很少有病例系列报道，这不足以证明这两种实体之间是否存在任何关联。
我们对当前关于GISTs与其他腹腔内恶性肿瘤同时发生的文献进行了综述。使用MEDLINE（数据库提供商PubMed）对文献进行电子检索。根据标题和摘要对相关研究进行初步筛选，然后根据出版物的全文进行二次筛选。
纳入了10个回顾性病例系列，共1108例GISTs患者。在所有研究的GISTs患者中，18%发现有同时存在的腹腔内恶性肿瘤。平均年龄为70.5岁，男性受影响更多（65%）。同时存在的GISTs的平均大小为18mm，最常见的与GIST相关的恶性肿瘤是胃腺癌。
GISTs与其他腹腔内原发性肿瘤的同时发生比人们认为的更常见，虽然目前尚不清楚GIST与其他恶性肿瘤同时发生是否存在因果关系，但由于已证实GIST患者发生第二种原发性肿瘤的患病率增加，尤其是在诊断后的第一年，因此需要对GIST患者进行更密切的监测。
