Department of General Surgery, University Hospital of Larissa, Larissa, Greece.
Department of Radiotherapy, University of Crete, Heraklion, Greece.
Int J Surg Oncol. 2021 Sep 1;2021:2626635. doi: 10.1155/2021/2626635. eCollection 2021.
Gastrointestinal stromal tumors (GISTs) quite frequently occur synchronously with other malignancies, with most cases being adenocarcinomas. GISTs and liposarcomas are both of mesenchymal origin, and their coexistence is extremely rare.
We conducted a review of the current literature regarding the synchronous occurrence of GISTs and intra-abdominal liposarcomas. An electronic search of the literature was undertaken using MEDLINE (database provider PubMed). Furthermore, we present the first described case of an 86-year-old male with a GIST and synchronous liposarcoma, both located in the stomach, as well as a 66-year-old male with a gastric GIST and concurrent retroperitoneal liposarcoma.
A total of 5 cases of synchronous GIST and intra-abdominal liposarcoma have been reported in the literature to date, with the most recent cases included in the present study.
Further research is required to explain any possible correlation in the coexistence of these different neoplasms of the same origin. Meanwhile, R0 resection of both tumors remains the treatment of choice.
胃肠道间质瘤（GISTs）常与其他恶性肿瘤同时发生，大多数为腺癌。GISTs 和脂肪肉瘤均来源于间叶组织，它们同时存在的情况极为罕见。
我们对 GISTs 和腹腔内脂肪肉瘤同时发生的相关文献进行了回顾。通过 MEDLINE（数据库提供商 PubMed）进行了电子文献检索。此外，我们还报告了首例 86 岁男性患者，他患有胃 GIST 和同时性的胃脂肪肉瘤，以及另一位 66 岁男性患者，他患有胃 GIST 和同时性的腹膜后脂肪肉瘤。
迄今为止，文献中总共报道了 5 例 GIST 和腹腔内脂肪肉瘤同时发生的病例，本研究纳入了最近的病例。
需要进一步研究以解释这些来源相同的不同肿瘤同时存在的可能相关性。同时，两种肿瘤的 R0 切除仍然是首选治疗方法。
