Department of Gynecology, Federal University of São Paulo, São Paulo, Brazil; Rey Juan Carlos University, Madrid, Spain; IVIRMA Madrid, Madrid, Spain.
Rey Juan Carlos University, Madrid, Spain; IVIRMA Madrid, Madrid, Spain.
Fertil Steril. 2019 Feb;111(2):205-211. doi: 10.1016/j.fertnstert.2018.11.021. Epub 2019 Jan 2.
The evaluation of embryo viability is typically based on morphologic and morphometric grading systems, which are known to be heavily affected by differences in subjective judgement. A significant proportion of euploid embryos do not implant even when the endometrium is normal, despite the wide incorporation of preimplantation genetic testing for aneuploidy. The need to improve reproductive outcomes following assisted reproductive treatments is culminating in the emergence of new research and technology with the potential to enhance embryo selection. The assessment of mitochondrial DNA content as a predictor of embryo viability has gained increasing attention among numerous promising approaches. As is common with new tools, this attention has led to both inflated expectations and serious disillusionment. Here we gather evidence to establish the true clinical applicability of this method. Controversy continues to surround this topic, adding both interest and confusion.
胚胎活力的评估通常基于形态学和形态计量学分级系统，这些系统已知受到主观判断差异的严重影响。尽管广泛采用了胚胎植入前非整倍体基因检测，但即使子宫内膜正常，仍有相当一部分整倍体胚胎无法着床。辅助生殖治疗后提高生殖结局的需求导致新的研究和技术的出现，这些技术有可能增强胚胎选择。线粒体 DNA 含量作为胚胎活力预测指标的评估在众多有前途的方法中受到越来越多的关注。与新工具一样，这种关注既带来了过高的期望，也带来了严重的失望。在这里，我们收集证据来确定这种方法的真正临床适用性。这个话题仍存在争议，既增加了人们的兴趣，也带来了困惑。
