Penn State College of Medicine, Hershey, Pennsylvania.
Fertil Steril. 2019 Feb;111(2):195-196. doi: 10.1016/j.fertnstert.2018.12.019.
This introduction reviews the background of mitochondrial transplantation. Its goals are to provide both basic and clinical insights into mitochondria and reproduction. The articles will review the biology of mitochondria, mitochondrial DNA, mitochondrial dynamics, and mitochondrial stress (unfolded protein response), discuss novel imaging technology, fluorescent lifetime imaging microscopy to visualize mitochondria and their function in oocytes and early embryos, provide a critical and objective review of the data suggesting and refuting the possible use of mitochondrial DNA as well as other emerging technologies as a biomarker for embryo viability and finally to review the use of mitochondria as a rejuvenation tool in human in vitro fertilization.
这篇介绍综述了线粒体移植的背景。它的目的是为线粒体和生殖的基础和临床研究提供见解。文章将综述线粒体、线粒体 DNA、线粒体动力学和线粒体应激（未折叠蛋白反应）的生物学，讨论新的成像技术，荧光寿命成像显微镜来可视化卵母细胞和早期胚胎中的线粒体及其功能，对提示和反驳可能使用线粒体 DNA 以及其他新兴技术作为胚胎活力生物标志物的这些数据进行批判性和客观的评价，最后综述了在人类体外受精中使用线粒体作为一种恢复活力的工具。
