Park Kyung-Ah, Oh Sei Yeul, Min Ju-Hong, Kim Byoung Joon
Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Ilwon-dong, Kangnam-gu, Seoul, Republic of Korea.
Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Graefes Arch Clin Exp Ophthalmol. 2019 Mar;257(3):651-655. doi: 10.1007/s00417-018-04217-7. Epub 2019 Jan 5.
To describe the incidence and timing of recurrence in patients with optic neuritis (ON).
Medical documents of adult patients with ON were retrospectively reviewed. The incidence and timing of recurrence of an ON episode were analyzed.
One hundred eleven patients with ON were included in this study. Their mean follow-up duration was 4.1 ± 3.1 years. Seven relapses occurred after intravenous methylprednisolone treatment. The estimated cumulative incidence of recurrence in either eye was 26% at 1 year, 33% at 3 years, 37% at 5 years, and 50% at 10 years after the first episode of ON. If there was no recurrence until 6 months after the first episode of ON, the next 5-year recurrence-free survival probability was 67%. If there was no recurrence until 1 year, the next 5-year survival probability was 72%. If there was no recurrence until 2 years, the next 5-year survival probability was 81%. Relapse within 1 month and the presence of neuromyelitis optica-immunoglobulin G were factors that increased the recurrence rate over time.
We evaluated the incidence and timing of the recurrence in patients with ON after the first episode. Lower probability of recurrence was observed in patients with longer recurrence-free follow-up period. However, monitoring for recurrence is needed even in patients with a single episode of ON due to the increasing tendency of the estimated cumulative incidence of recurrence over many years.
描述视神经炎（ON）患者复发的发生率及时间。
对成年ON患者的医疗文件进行回顾性分析。分析ON发作复发的发生率及时间。
本研究纳入111例ON患者。他们的平均随访时间为4.1±3.1年。静脉注射甲泼尼龙治疗后发生7次复发。首次ON发作后1年，单眼复发的估计累积发生率为26%，3年为33%，5年为37%，10年为50%。如果在首次ON发作后6个月内未复发，接下来5年无复发存活概率为67%。如果在1年内未复发，接下来5年存活概率为72%。如果在2年内未复发，接下来5年存活概率为81%。1个月内复发以及存在视神经脊髓炎免疫球蛋白G是随时间增加复发率的因素。
我们评估了首次发作后ON患者复发的发生率及时间。复发无随访期较长的患者复发概率较低。然而，由于多年来估计累积复发发生率呈上升趋势，即使是单次发作的ON患者也需要监测复发情况。
