Department of Anesthesiology, Center for Translational Research in Neurodegenerative Disease, McKnight Brain Institute, University of Florida, Gainesville, FL, USA.
Departments of Neurology, Psychiatry, Pharmaceutics, Psychology, and Neuroscience, University of Florida College of Medicine, 1275 Center Drive, Biomed Science Building J493, PO 100159, Gainesville, FL, 32610, USA.
Mol Neurobiol. 2019 Aug;56(8):5483-5496. doi: 10.1007/s12035-018-1440-y. Epub 2019 Jan 5.
Novel and innovative methods are critical in fostering new treatments and improving clinical outcomes in patients who suffer from ischemic stroke. Bilirubin has long been considered metabolic waste that can be harmful to the body; however, it is now becoming recognized as one of the body's most potent antioxidant, anti-inflammatory, and neuroprotective molecules. These properties facilitate bilirubin's anti-atherogenic effects to impede and prevent the formation of thrombi in ischemic stroke. These functions allow for protection from neuronal injury during an ischemic state and suggest that elevated bilirubin levels may be linked to a lower rate of morbidity and mortality. Therefore, here we discuss the pathophysiology of stroke and the molecular properties of bilirubin to better understand their beneficial relationship. We outline clinical studies looking at the relationship between serum bilirubin levels and ischemic stroke prevalence. At this time, few studies have rigorously looked at the relationship between bilirubin and ischemic stroke, whether it is positive or negative. Thus, rigorous research is needed to provide evidence supporting the current studies, expand on these studies, and facilitate their translation to bedside therapy for patients who suffer from ischemic stroke.
在培养新的治疗方法和改善缺血性中风患者的临床结果方面，新颖创新的方法至关重要。胆红素长期以来一直被认为是对身体有害的代谢废物;然而，现在它被认为是身体最有效的抗氧化剂、抗炎剂和神经保护分子之一。这些特性促进了胆红素的抗动脉粥样硬化作用，从而阻止和预防缺血性中风中血栓的形成。这些功能可以防止神经元在缺血状态下受到损伤，并表明胆红素水平升高可能与发病率和死亡率降低有关。因此，在这里我们讨论中风的病理生理学和胆红素的分子特性，以更好地理解它们之间有益的关系。我们概述了研究血清胆红素水平与缺血性中风患病率之间关系的临床研究。目前，很少有研究严格观察胆红素与缺血性中风之间的关系，无论是积极的还是消极的。因此，需要进行严格的研究，为目前的研究提供证据支持，扩展这些研究，并将其转化为缺血性中风患者的床边治疗。
