Health and Nutrition Faculty, Tabriz University of Medical Sciences, Golgasht St., Attar Neishaboori Ave, Tabriz, Iran.
Biol Trace Elem Res. 2012 Dec;150(1-3):42-8. doi: 10.1007/s12011-012-9487-5. Epub 2012 Aug 17.
Given the conflicting results about the positive effects of magnesium and L-carnitine and as there is no report concerning concurrent supplementation of magnesium and L-carnitine on migraine prophylaxis, the effects of magnesium, L-carnitine, and concurrent magnesium-L-carnitine supplementation on migraine indicators were assessed. In this clinical trial, 133 migrainous patients were randomly assigned into three intervention groups: magnesium oxide (500 mg/day), L-carnitine (500 mg/day), and Mg-L-carnitine (500 mg/day magnesium and 500 mg/day L-carnitine), and a control group. After 12 weeks of supplementation, the checklist of migraine indicators including migraine attacks/month, migraine days/month, and headache severity was completed, and serum concentrations of magnesium and L-carnitine were measured by atomic absorption spectrophotometry and enzymatic UV test, respectively. The results showed a significant reduction in all migraine indicators in all studied groups (p < 0.05). The ANOVA results showed a significant reduction in migraine frequency across various supplemented and control groups (p = 0.008). By separating the effects of magnesium supplementation from other confounding factors such as routine treatments using the repeated measures and nested model, it was clarified that magnesium supplementation had a significant effect on all migraine indicators. Oral supplementation with magnesium oxide and L-carnitine and concurrent supplementation of Mg-L-carnitine besides routine treatments could be effective in migraine prophylaxis; however, larger trials are needed to confirm these preliminary findings.
鉴于镁和左旋肉碱对偏头痛预防的积极作用存在相互矛盾的结果，且尚无关于镁和左旋肉碱同时补充对偏头痛预防作用的报道，本研究评估了镁、左旋肉碱以及同时补充镁-左旋肉碱对偏头痛相关指标的影响。在这项临床试验中，133 例偏头痛患者被随机分为三组干预组：氧化镁（500mg/天）、左旋肉碱（500mg/天）和 Mg-L-肉碱（500mg/天镁和 500mg/天左旋肉碱），以及对照组。补充 12 周后，通过偏头痛相关指标检查表（包括每月偏头痛发作次数、每月偏头痛天数和头痛严重程度）完成评估，并用原子吸收分光光度法和酶促 UV 试验分别测量血清镁和左旋肉碱浓度。结果表明，所有研究组的所有偏头痛相关指标均显著降低（p<0.05）。方差分析结果显示，各种补充组和对照组的偏头痛发作频率均显著降低（p=0.008）。通过使用重复测量和嵌套模型将镁补充的作用与常规治疗等其他混杂因素分开，可以明确镁补充对所有偏头痛指标均有显著影响。除常规治疗外，口服氧化镁和左旋肉碱以及同时补充 Mg-L-肉碱可能对偏头痛预防有效；但需要更大规模的试验来证实这些初步发现。
