Huo Yu-Feng, Wang Huai-Li, Wei Er-Hu, Jia Pei-Sheng, Liu Hui-Qiong, Fan Xiao-Lei, Yana Kun-Li
Department of Pediatrics, The First Affiliated Hospital of Zhengzhou University , Zhengzhou 450052 , China.
J Asian Nat Prod Res. 2019 Nov;21(11):1083-1089. doi: 10.1080/10286020.2018.1513919. Epub 2019 Jan 6.
Aiming to investigate the bioactive constituents with anti-inflammatory activity from the roots of , two new compounds ( and ) were isolated from the extract of the roots of the plant. Their structures were elucidated on the basis of spectral analyses (UV, IR, NMR, and MS spectroscopy), as well as experimental and calculated electronic circular dichroism (ECD) analyses. All of the isolates were tested for their anti-inflammatory properties in terms of suppressing the production of NO in lipopolysaccharide-induced BV2 cells. Compound exhibited stronger anti-inflammatory effects (77.65%) than the positive control curcumin (69.75%) at 10 M.
为了从该植物的根中研究具有抗炎活性的生物活性成分,从该植物根的提取物中分离出两种新化合物(化合物1和化合物2)。它们的结构是基于光谱分析(紫外、红外、核磁共振和质谱光谱)以及实验和计算的电子圆二色性(ECD)分析确定的。所有分离物均在抑制脂多糖诱导的BV2细胞中一氧化氮产生方面测试了其抗炎特性。在10 μM时,化合物1表现出比阳性对照姜黄素(69.75%)更强的抗炎作用(77.65%)。