Li Jing, Huang Xiaoyan, Du Xianjie, Sun Wenji, Zhang Yongmin
Provincial Key Laboratory of Biomedicine, Northwest University, Shaanxi, P R China.
Nat Prod Res. 2009;23(8):775-80. doi: 10.1080/14786410802696247.
Two saponins: scrokoelziside A (1), scrokoelziside B (2), one iridoid glycoside, eurostoside (3), and two flavonoids: nepitrin (4) and homoplantaginin (5), were isolated from the leaves of Scrophularia ningpoensis for the first time. Moreover, eight known compounds: cane sugar (6), harpagide (7), aucubin (8), 6-O-methylcatalpol (9), harpagoside (10), angoroside C (11), beta-sitosterol (12) and beta-sitosterol glucoside (13) were isolated from the roots of S. ningpoensis. Furthermore, the antimicrobial activity of the extracts of the leaves of S. ningpoensis and the 10 compounds (1, 2, 3, 4, 5, 7, 8, 9, 10, 11) was studied in vitro against eight reference strains of bacteria by using the disc-diffusion method and micro-well dilution assay. The extracts of leaves and scrokoelziside A are effective against beta-haemolytic streptococci but had no effect against other strains. The extract of roots and other compounds showed no activity against all bacterial strains at the test concentration.
玄参皂苷A（1）、玄参皂苷B（2），一种环烯醚萜苷，桃叶珊瑚苷（3），以及两种黄酮类化合物：尼泊尔鸢尾素（4）和高车前苷（5）。此外，从宁波玄参根中分离出8种已知化合物：蔗糖（6）、哈帕苷（7）、桃叶珊瑚苷（8）、6 - O - 甲基梓醇（9）、哈巴苷（10）、安格洛苷C（11）、β - 谷甾醇（12）和β - 谷甾醇葡萄糖苷（13）。此外，采用纸片扩散法和微孔稀释法，体外研究了宁波玄参叶提取物及10种化合物（1、2、3、4、5、7、8、9、10、11）对8种参考菌株的抗菌活性。叶提取物和玄参皂苷A对β - 溶血性链球菌有效，但对其他菌株无效。根提取物和其他化合物在测试浓度下对所有细菌菌株均无活性。
