Ural Federal University, Yekaterinburg, Russia.
Ural Federal University, Yekaterinburg, Russia.
Prog Biophys Mol Biol. 2019 Aug;145:85-104. doi: 10.1016/j.pbiomolbio.2018.12.011. Epub 2019 Jan 3.
Models of the transport of substances in protocells are considered from first physicochemical principles. Functional similarities and differences in the transport systems of archaea, cyanobacteria, E. coli, and diatoms have been analyzed. Based on the selection of the most important transport systems, a model of transport of substances through the membrane of the last universal common ancestor, LUCA, was constructed. Models of isotope separation in protocells were considered. Based on the proposed models, the difference in isotope concentrations in rocks can be predicted, which can serve as an indicator of the presence of life in the early stages of evolution. Mechanisms of energy conversion for the simplest forms of directed motion in protocells are considered. A special stage in the evolution of protocells is proposed - the minimal mobile cell.
从第一性物理化学原理出发，考虑了原细胞中物质输运的模型。分析了古菌、蓝藻、大肠杆菌和硅藻的输运系统的功能相似性和差异。基于对最重要输运系统的选择，构建了通过最后共同祖先 LUCA 的膜的物质输运模型。还考虑了原细胞中同位素分离的模型。基于所提出的模型，可以预测原细胞中同位素浓度的差异，这可以作为进化早期生命存在的指标。还考虑了原细胞中最简单定向运动的能量转换机制。提出了原细胞进化的一个特殊阶段——最小移动细胞。
