CONICET - Universidad de Buenos Aires, Centro de Investigaciones en Hidratos de Carbono (CIHIDECAR), Intendente Güiraldes 2160, Buenos Aires PC:1428, Argentina.
CONICET - Universidad de Buenos Aires, Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales (IQUIBICEN), Intendente Güiraldes 2160, Buenos Aires PC:1428, Argentina.
Bioorg Med Chem Lett. 2019 Feb 15;29(4):556-559. doi: 10.1016/j.bmcl.2018.12.063. Epub 2019 Jan 2.
In this work, several ribavirin analogues were synthesized and incorporated into a multivalent arrangement. Both were subsequently modified by the addition of polyhydroxylated residues. Their antiviral activity was tested against Junín virus, etiological agent responsible of Argentine hemorrhagic fever. Some compounds inhibited Junín virus in the range of 13.2-389.1 µM. Two modified ribavirin analogues presented an effective concentration comparable to ribavirin but with a higher selectivity index.
在这项工作中，合成了几种利巴韦林类似物，并将其整合到多价排列中。随后通过添加多羟基化残基对它们进行了修饰。它们的抗病毒活性针对导致阿根廷出血热的病原体胡宁病毒进行了测试。一些化合物在 13.2-389.1µM 的范围内抑制了胡宁病毒。两种修饰的利巴韦林类似物的有效浓度与利巴韦林相当，但选择性指数更高。
