Institute of Specific Prophylaxis and Tropical Medicine, Centre for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Kinderspitalgasse 15, A-1090 Vienna, Austria.
Institute of Specific Prophylaxis and Tropical Medicine, Centre for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Kinderspitalgasse 15, A-1090 Vienna, Austria.
Int J Antimicrob Agents. 2019 Feb;53(2):116-127. doi: 10.1016/j.ijantimicag.2018.10.016. Epub 2018 Oct 27.
Trichomonas vaginalis is the causative agent of the most common non-viral sexually transmitted disease worldwide. The infection may be associated with severe complications, including infertility, preterm labour, cancer and an increased risk of human immunodeficiency virus (HIV) transmission. Treatment remains almost exclusively based on 5-nitroimidazoles, but resistance is on the rise. This article provides an overview of clinically evaluated systemic and topical treatment options for human trichomoniasis and summarises the current state of knowledge on various herbal, semisynthetic and synthetic compounds evaluated for their anti-Trichomonas efficacy in vitro.
阴道毛滴虫是全球最常见的非病毒性性传播疾病的病原体。该感染可能与严重并发症相关，包括不孕、早产、癌症和人类免疫缺陷病毒（HIV）传播风险增加。治疗仍然几乎完全基于 5-硝基咪唑类药物，但耐药性正在上升。本文概述了经临床评估的治疗人类滴虫病的全身和局部治疗方案，并总结了目前各种评估其抗滴虫疗效的草药、半合成和合成化合物的知识现状。
