原生生物寄生虫分子生物学的最新进展
Recent advances in the molecular biology of the protist parasite .
作者信息
Leitsch David
机构信息
Department of Specific Prophylaxis and Tropical Medicine, Medical University of Vienna, Vienna, Austria.
出版信息
Fac Rev. 2021 Mar 4;10:26. doi: 10.12703/r/10-26. eCollection 2021.
Abstract
is an anaerobic/microaerophilic protist parasite which causes trichomoniasis, one of the most prevalent sexually transmitted diseases worldwide. . not only is important as a human pathogen but also is of great biological interest because of its peculiar cell biology and metabolism, in earlier times fostering the erroneous notion that this microorganism is at the root of eukaryotic evolution. This review summarizes the major advances in the last five years in the . field with regard to genetics, molecular biology, ecology, and pathogenicity of the parasite.
摘要
是一种厌氧/微需氧原生生物寄生虫，可引起滴虫病，这是全球最普遍的性传播疾病之一。……不仅作为人类病原体很重要，而且由于其独特的细胞生物学和新陈代谢，也具有极大的生物学研究价值，在早期引发了关于这种微生物是真核生物进化根源的错误观念。本综述总结了过去五年在该寄生虫的遗传学、分子生物学、生态学和致病性等领域的主要进展。
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2
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Front Cell Infect Microbiol. 2020 Nov 5;10:591172. doi: 10.3389/fcimb.2020.591172. eCollection 2020.
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