Laboratory of Microvascular Medicine, Medical Research Center, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong, China.
The Research Center for Advanced Science and Technology, Isotope Science Center, The University of Tokyo, Meguro-ku, Tokyo, Japan.
Theranostics. 2018 Nov 26;8(21):6053-6069. doi: 10.7150/thno.30305. eCollection 2018.
Identified as a major downstream effector of the small GTPase RhoA, Rho-associated coiled-coil kinase (ROCK) is a versatile regulator of multiple cellular processes. Angiogenesis, the process of generating new capillaries from the pre-existing ones, is required for the development of various diseases such as cancer, diabetes and rheumatoid arthritis. Recently, ROCK has attracted attention for its crucial role in angiogenesis, making it a promising target for new therapeutic approaches. In this review, we summarize recent advances in understanding the role of ROCK signaling in regulating the permeability, migration, proliferation and tubulogenesis of endothelial cells (ECs), as well as its functions in non-ECs which constitute the pro-angiogenic microenvironment. The therapeutic potential of ROCK inhibitors in angiogenesis-related diseases is also discussed.
被鉴定为小 GTPase RhoA 的主要下游效应物，Rho 相关卷曲螺旋激酶（ROCK）是多种细胞过程的多功能调节剂。血管生成，即从预先存在的血管中生成新毛细血管的过程，是多种疾病（如癌症、糖尿病和类风湿性关节炎）发展所必需的。最近，ROCK 因其在血管生成中的关键作用而受到关注，使其成为新的治疗方法的有前途的靶点。在这篇综述中，我们总结了近年来对 ROCK 信号在调节内皮细胞（EC）的通透性、迁移、增殖和管状形成，以及在构成促血管生成微环境的非 EC 中的功能的理解的最新进展。还讨论了 ROCK 抑制剂在与血管生成相关的疾病中的治疗潜力。
