Clinic of Internal Medicine II, Department of Cardiology, Paracelsus Medical University of Salzburg, Austria.
Division of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty, University Duesseldorf, Germany.
Theranostics. 2018 Jul 1;8(14):3974-3976. doi: 10.7150/thno.27154. eCollection 2018.
The pathogenesis of diabetes involves dysregulated gene expression on a pre- and posttranscriptional level. One key mechanism in the development and progression of diabetes is thought being a dysregulation of signalling mediators such as microRNAs. These microRNAs interfere with pathophysiological reactions in diabetes by affecting gene transcription, insulin resistance and endothelial dysfunction. Here, in this current issue, Stępień et al. analysed ectosomal miRNA patterns in patients with type 2 diabetes mellitus (T2DM) using different analytical techniques. The focus of the current analysis was to characterize pro- and anti-angiogenic signalling effects of ectosomal miRNAs revealing important pathophysiologic mechanisms and signalling in T2DM.
糖尿病的发病机制涉及转录前和转录后基因表达失调。在糖尿病的发生和发展过程中，一个关键机制被认为是信号转导介质（如 microRNAs）的失调。这些 microRNAs 通过影响基因转录、胰岛素抵抗和内皮功能障碍来干扰糖尿病的病理生理反应。在本期中，Stępień 等人使用不同的分析技术分析了 2 型糖尿病（T2DM）患者的外泌体 miRNA 模式。目前分析的重点是表征外泌体 miRNA 的促血管生成和抗血管生成信号作用，揭示 T2DM 中的重要病理生理机制和信号转导。
