University College London, Department of Mechanical Engineering, Multiscale Cardiovascular Engineering Group, UK.
WEISS Centre for Surgical and Interventional Sciences, University College London, UK.
Theranostics. 2018 Dec 7;8(22):6384-6385. doi: 10.7150/thno.30753. eCollection 2018.
The use of in silico tools for the interventional planning of complex vascular conditions, such as Aortic Dissections has been often limited by high computational cost, involving long timescales for accurate results to be produced and low numbers of patients, precluding the use of statistical analyses to inform individual-level models. In the paper [ 2018; 8(20):5758-5771. doi:10.7150/thno.28944], Chen proposed a novel algorithm to compute patient-specific 'virtual TEVAR' that will help clinicians to approach individual treatment and decision-making based on objective and quantifiable metrics and validated on a cohort of 66 patients in real time. This research will significantly impact the field and has the potential to transform the way clinical interventions will be approached in the future.
使用计算机模拟工具来规划复杂的血管状况(如主动脉夹层)的介入治疗计划,往往受到计算成本高的限制,需要花费很长时间才能得出准确的结果,并且患者数量较少,这使得统计分析无法用于为个体模型提供信息。在[2018; 8(20):5758-5771. doi:10.7150/thno.28944]这篇论文中,Chen 提出了一种计算患者特定的“虚拟 TEVAR”的新算法,这将有助于临床医生根据客观和可量化的指标来处理个体化的治疗和决策,并在 66 名实时患者的队列中进行验证。这项研究将对该领域产生重大影响,并有可能改变未来临床干预的方法。