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1
Comment on 'Cardiac effects of 6 months' dietary nitrate and spironolactone in patients with hypertension and with/at risk of type 2 diabetes, in the factorial design, double-blind, randomised controlled VaSera trial' by Faconti et al.对法孔蒂等人的《在析因设计、双盲、随机对照的VaSera试验中，6个月膳食硝酸盐和螺内酯对高血压合并2型糖尿病及有2型糖尿病风险患者的心脏影响》的评论
Br J Clin Pharmacol. 2019 May;85(5):1035-1036. doi: 10.1111/bcp.13835. Epub 2019 Jan 4.
2
Reply to 'Comment on 'Cardiac effects of 6 months' dietary nitrate and spironolactone in patients with hypertension and with/at risk of type 2 diabetes, in the factorial design, double-blind, randomised controlled VaSera trial' by Faconti et al.'.对法孔蒂等人《对“在析因设计、双盲、随机对照的VaSera试验中，6个月膳食硝酸盐和螺内酯对高血压合并2型糖尿病及有2型糖尿病风险患者的心脏影响”的评论》的回复
Br J Clin Pharmacol. 2019 May;85(5):1037-1038. doi: 10.1111/bcp.13890. Epub 2019 Mar 4.
3
Cardiac effects of 6 months' dietary nitrate and spironolactone in patients with hypertension and with/at risk of type 2 diabetes, in the factorial design, double-blind, randomized controlled VaSera trial.在因子设计、双盲、随机对照 VaSera 试验中，研究了 6 个月饮食硝酸盐和螺内酯对高血压伴/有 2 型糖尿病风险患者的心脏影响。
Br J Clin Pharmacol. 2019 Jan;85(1):169-180. doi: 10.1111/bcp.13783. Epub 2018 Nov 13.
4
Dietary nitrate prevents progression of carotid subclinical atherosclerosis through blood pressure-independent mechanisms in patients with or at risk of type 2 diabetes mellitus.饮食硝酸盐通过独立于血压的机制预防 2 型糖尿病或有 2 型糖尿病风险患者的颈动脉亚临床动脉粥样硬化进展。
Br J Clin Pharmacol. 2021 Dec;87(12):4726-4736. doi: 10.1111/bcp.14897. Epub 2021 May 29.
5
Low dose spironolactone reduces blood pressure in patients with resistant hypertension and type 2 diabetes mellitus: a double blind randomized clinical trial.低剂量螺内酯可降低耐药性高血压合并 2 型糖尿病患者的血压：一项双盲随机临床试验。
J Hypertens. 2013 Oct;31(10):2094-102. doi: 10.1097/HJH.0b013e3283638b1a.
6
Reducing Arterial Stiffness Independently of Blood Pressure: The VaSera Trial.独立于血压降低动脉僵硬度：VaSera试验
J Am Coll Cardiol. 2017 Sep 26;70(13):1683-1684. doi: 10.1016/j.jacc.2017.07.765.
7
Low-dose spironolactone reduces plasma fibulin-1 levels in patients with type 2 diabetes and resistant hypertension.低剂量螺内酯可降低2型糖尿病合并顽固性高血压患者的血浆纤连蛋白-1水平。
J Hum Hypertens. 2015 Jan;29(1):28-32. doi: 10.1038/jhh.2014.27. Epub 2014 Apr 17.
8
Letter regarding article by Hood et al, "The Spironolactone, Amiloride, Losartan, and Thiazide (SALT) double-blind crossover trial in patients with low-renin hypertension and elevated aldosterone-renin ratio".关于胡德等人所著文章《螺内酯、阿米洛利、氯沙坦与噻嗪类药物（SALT）治疗低肾素性高血压及醛固酮-肾素比值升高患者的双盲交叉试验》的信函
Circulation. 2008 Feb 5;117(5):e151; author reply e152. doi: 10.1161/CIRCULATIONAHA.107.738757.
9
Sodium restriction and blood pressure in hypertensive type II diabetics: randomised blind controlled and crossover studies of moderate sodium restriction and sodium supplementation.II型糖尿病高血压患者的钠限制与血压：适度钠限制和钠补充的随机双盲对照及交叉研究
BMJ. 1989 Jan 28;298(6668):227-30. doi: 10.1136/bmj.298.6668.227.
10
A double-blind, randomized study comparing the antihypertensive effect of eplerenone and spironolactone in patients with hypertension and evidence of primary aldosteronism.一项比较依普利酮和螺内酯在高血压合并原发性醛固酮增多症患者降压效果的双盲、随机研究。
J Hypertens. 2011 May;29(5):980-90. doi: 10.1097/HJH.0b013e3283455ca5.

引用本文的文献

1
Reply to 'Comment on 'Cardiac effects of 6 months' dietary nitrate and spironolactone in patients with hypertension and with/at risk of type 2 diabetes, in the factorial design, double-blind, randomised controlled VaSera trial' by Faconti et al.'.对法孔蒂等人《对“在析因设计、双盲、随机对照的VaSera试验中，6个月膳食硝酸盐和螺内酯对高血压合并2型糖尿病及有2型糖尿病风险患者的心脏影响”的评论》的回复
Br J Clin Pharmacol. 2019 May;85(5):1037-1038. doi: 10.1111/bcp.13890. Epub 2019 Mar 4.

本文引用的文献

1
Cardiac effects of 6 months' dietary nitrate and spironolactone in patients with hypertension and with/at risk of type 2 diabetes, in the factorial design, double-blind, randomized controlled VaSera trial.在因子设计、双盲、随机对照 VaSera 试验中，研究了 6 个月饮食硝酸盐和螺内酯对高血压伴/有 2 型糖尿病风险患者的心脏影响。
Br J Clin Pharmacol. 2019 Jan;85(1):169-180. doi: 10.1111/bcp.13783. Epub 2018 Nov 13.
2
Nitrite exerts antioxidant effects, inhibits the mTOR pathway and reverses hypertension-induced cardiac hypertrophy.亚硝酸盐发挥抗氧化作用，抑制 mTOR 通路，逆转高血压引起的心肌肥厚。
Free Radic Biol Med. 2018 May 20;120:25-32. doi: 10.1016/j.freeradbiomed.2018.03.006. Epub 2018 Mar 9.
3
Chronic administration of sodium nitrite prevents hypertension and protects arterial endothelial function by reducing oxidative stress in angiotensin II-infused mice.慢性给予亚硝酸钠可通过减少血管紧张素 II 输注小鼠的氧化应激来预防高血压和保护动脉内皮功能。
Vascul Pharmacol. 2018 Mar;102:11-20. doi: 10.1016/j.vph.2017.05.003. Epub 2017 May 26.
4
A high fat diet induces sex-specific differences in hepatic lipid metabolism and nitrite/nitrate in rats.高脂饮食会在大鼠肝脏脂质代谢以及亚硝酸盐/硝酸盐方面引发性别特异性差异。
Nitric Oxide. 2016 Apr 1;54:51-9. doi: 10.1016/j.niox.2016.02.007. Epub 2016 Feb 26.
5
Gastric S-nitrosothiol formation drives the antihypertensive effects of oral sodium nitrite and nitrate in a rat model of renovascular hypertension.胃内S-亚硝基硫醇的形成介导口服亚硝酸钠和硝酸钠对肾血管性高血压大鼠模型的降压作用。
Free Radic Biol Med. 2015 Oct;87:252-62. doi: 10.1016/j.freeradbiomed.2015.06.038. Epub 2015 Jul 6.
6
The antihypertensive effects of sodium nitrite are not associated with circulating angiotensin converting enzyme inhibition.亚硝酸钠的降压作用与循环中血管紧张素转换酶抑制无关。
Nitric Oxide. 2014 Aug 31;40:52-9. doi: 10.1016/j.niox.2014.05.009. Epub 2014 May 27.
7
Diabetes and hypertension: is there a common metabolic pathway?糖尿病与高血压：是否存在共同的代谢途径？
Curr Atheroscler Rep. 2012 Apr;14(2):160-6. doi: 10.1007/s11883-012-0227-2.
8
Dietary nitrite attenuates oxidative stress and activates antioxidant genes in rat heart during hypobaric hypoxia.低氧环境下饮食亚硝酸盐可减轻大鼠心脏氧化应激并激活抗氧化基因。
Nitric Oxide. 2012 Jan 1;26(1):61-73. doi: 10.1016/j.niox.2011.12.002. Epub 2011 Dec 14.
9
Activation of mTOR/p70S6 kinase by ANG II inhibits insulin-stimulated endothelial nitric oxide synthase and vasodilation.血管紧张素 II 通过激活 mTOR/p70S6 激酶抑制胰岛素刺激的内皮型一氧化氮合酶和血管舒张。
Am J Physiol Endocrinol Metab. 2012 Jan 15;302(2):E201-8. doi: 10.1152/ajpendo.00497.2011. Epub 2011 Oct 25.
10
The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics.生理学与治疗学中的硝酸盐-亚硝酸盐-一氧化氮途径
Nat Rev Drug Discov. 2008 Feb;7(2):156-67. doi: 10.1038/nrd2466.

Comment on 'Cardiac effects of 6 months' dietary nitrate and spironolactone in patients with hypertension and with/at risk of type 2 diabetes, in the factorial design, double-blind, randomised controlled VaSera trial' by Faconti et al.

作者信息

Guimaraes Danielle Aparecida, Tanus-Santos Jose Eduardo

机构信息

Department of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, SP, Brazil.

出版信息

Br J Clin Pharmacol. 2019 May;85(5):1035-1036. doi: 10.1111/bcp.13835. Epub 2019 Jan 4.

DOI:10.1111/bcp.13835
PMID:30614030
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6475684/
Abstract
摘要