University of Connecticut School of Pharmacy, Storrs, Connecticut.
UConn/Hartford Hospital HOPES Group, Hartford, Connecticut.
Oral Dis. 2019 Apr;25(3):720-725. doi: 10.1111/odi.13034. Epub 2019 Jan 25.
Conduct a PROSPERO registered (CRD42018105227) systematic review of the efficacy of curcumin in the treatment of oral lichen planus (OLP).
Medline from the earliest possible date to the present (December 18, 2018) using the terms "turmeric" OR "curcumin" OR "curcuma" AND "oral lichen planus".
Studies assessing patient outcomes in OLP. There were four trials assessing the comparative efficacy of topical curcumin vs. topical corticosteroids and three trials assessing the efficacy of oral curcumin vs. placebo.
Clinical and methodological heterogeneity precluded statistical pooling. There were many limitations in the literature weakening the strength and applicability of evidence. Topical curcumin provided reductions in pain, burning, and clinical manifestations of OLP versus baseline, effects similar or inferior to topical corticosteroids. In oral curcumin trials, there were no significant benefits of curcumin therapy versus placebo but there were some potential benefits and reasonable safety in an observational extension study.
It is difficult to determine whether topical or oral curcumin is a viable therapy for oral lichen planus. Topically applied curcumin in particular shows promising preliminary data but would likely not supplant topical corticosteroids as the modality of choice for most patients.
对姜黄素治疗口腔扁平苔藓（OLP）的疗效进行 PROSPERO 注册（CRD42018105227）系统评价。
使用术语“ turmeric”或“curcumin”或“curcuma”和“oral lichen planus”，从最早可能的日期到目前（2018 年 12 月 18 日）检索 Medline。
评估 OLP 患者结局的研究。有四项研究评估了局部姜黄素与局部皮质类固醇的比较疗效，三项研究评估了口服姜黄素与安慰剂的疗效。
临床和方法学的异质性排除了统计学的合并。文献中有许多局限性，削弱了证据的强度和适用性。与基线相比，局部姜黄素可减轻 OLP 的疼痛、烧灼感和临床表现，其效果与局部皮质类固醇相似或稍差。在口服姜黄素试验中，与安慰剂相比，姜黄素治疗没有显著益处，但在一项观察性扩展研究中，有一些潜在的益处和合理的安全性。
很难确定局部或口服姜黄素是否是口腔扁平苔藓的可行治疗方法。局部应用的姜黄素尤其显示出有希望的初步数据，但不太可能取代大多数患者首选的局部皮质类固醇。
