KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul, 02841, Republic of Korea.
Department of Bioengineering, University of Washington, Seattle, WA, 98109, USA.
Adv Healthc Mater. 2019 Feb;8(4):e1801332. doi: 10.1002/adhm.201801332. Epub 2019 Jan 7.
Cells respond and actively adapt to environmental cues in the form of mechanical stimuli. This extends to immune cells and their critical role in the maintenance of tissue homeostasis. Multiple recent studies have begun illuminating underlying mechanisms of mechanosensation in modulating immune cell phenotypes. Since the extracellular microenvironment is critical to modify cellular physiology that ultimately determines the functionality of the cell, understanding the interactions between immune cells and their microenvironment is necessary. This review focuses on mechanoregulation of immune responses mediated by macrophages, dendritic cells, and T cells, in the context of modern mechanobiology.
细胞以机械刺激的形式对环境信号做出反应并积极适应。这同样适用于免疫细胞及其在维持组织动态平衡中的关键作用。最近多项研究开始揭示机械感受在调节免疫细胞表型中的潜在机制。由于细胞外微环境对于改变细胞生理学至关重要，而细胞生理学最终决定细胞的功能，因此了解免疫细胞及其微环境之间的相互作用是必要的。本综述重点关注现代机械生物学中巨噬细胞、树突状细胞和 T 细胞的免疫反应的机械调节。
