Department of Hematology/Oncology, Mayo Clinic, Jacksonville, Florida, USA.
Melanoma Res. 2019 Jun;29(3):322-324. doi: 10.1097/CMR.0000000000000577.
Inositol hexaphosphate (IP6) also called phytic acid is a polyphosphorylated carbohydrate naturally found in cereals, nuts, grains, and high-fiber-containing foods. It has been shown to inhibit the growth of many different tumor cell lines both in vitro and in vivo like colon, pancreas, liver, prostate, and even melanoma. Vitamin B inositol is a precursor of IP6 and another naturally occurring compound with anticancer properties. We present a case report of a patient with metastatic melanoma who declined traditional therapy and opted to try over the counter supplement IP6+inositol instead. To our surprise, the patient achieved a complete remission and remains in remission 3 years later. On the basis of this case and previous preclinical studies, we believe further research is indicated in exploring antiproliferative and potential immune stimulating effects of IP6+inositol in patients with metastatic melanoma.
肌醇六磷酸（IP6），也称为植酸，是一种天然存在于谷物、坚果、谷物和高纤维食物中的多磷酸化碳水化合物。它已被证明可以抑制许多不同的肿瘤细胞系的生长，无论是在体外还是体内，如结肠、胰腺、肝脏、前列腺，甚至黑色素瘤。维生素 B 肌醇是 IP6 的前体，也是另一种具有抗癌特性的天然化合物。我们报告了一例转移性黑色素瘤患者的病例，该患者拒绝传统治疗，选择尝试非处方补充剂 IP6+肌醇。令我们惊讶的是，患者获得了完全缓解，并且 3 年后仍处于缓解期。基于该病例和之前的临床前研究，我们认为进一步研究表明，在转移性黑色素瘤患者中，IP6+肌醇具有抗增殖和潜在的免疫刺激作用。
