Boroń-Kaczmarska A, Boroń P, Sokolewicz-Bobrowska E, Szpakowicz T, Rzewnicki I, Rogowska-Szadkowska D
Z Gesamte Inn Med. 1978 Feb 15;33(4):116-9.
In 15 patients with acute icteric viral hepatitis B the immunological reactivity was tested. The examinations were performed on the 1st, 7th, and 14th day of hospitalization. They consisted of the determination of the HBsAg and its antibodies in the serum, of the percentage of the B- and T-lymphocytes, of the lymphocyte transformation test under the influence of phytohaemagglutinin, of the lymphocyte migration inhibitory test when the HBsAg is present as well as of the determination of the IgG, IgA and the IgM-level. A decreased percentage of the T-lymphocytes, a decreased blastic transformation and an inhibition of the lymphocyte migration was proved. After a transient increase in the first and second examination the IgG-level returned to the normal in the third examination, whereas the IgM-level increased. Finally dynamics and importance of the cellular reactivity in the pathogenesis of viral hepatitis B are discussed.
对15例急性黄疸型乙型病毒性肝炎患者的免疫反应性进行了检测。检测在住院第1天、第7天和第14天进行。检测项目包括血清中HBsAg及其抗体的测定、B淋巴细胞和T淋巴细胞的百分比测定、植物血凝素作用下的淋巴细胞转化试验、HBsAg存在时的淋巴细胞迁移抑制试验以及IgG、IgA和IgM水平的测定。结果证实T淋巴细胞百分比降低、母细胞转化减少以及淋巴细胞迁移受到抑制。IgG水平在第一次和第二次检测时有短暂升高，第三次检测时恢复正常，而IgM水平升高。最后讨论了细胞反应性在乙型病毒性肝炎发病机制中的动态变化及重要性。
