Ono Yumie, Esaki Kimiya, Takahashi Yuta, Nakabayashi Mikie, Ichinose Masashi, Lee Kijoon
Department of Electronics and Bioinformatics, School of Science and Technology, Meiji University, 1-1-1 Higashi-Mita, Tama-ku, Kawasaki, Kanagawa 2148571, Japan.
Electrical Engineering Program, Graduate School of Science and Technology, Meiji University, 1-1-1 Higashi-Mita, Tama-ku, Kawasaki, Kanagawa 2148571, Japan.
Biomed Opt Express. 2018 Aug 29;9(9):4539-4551. doi: 10.1364/BOE.9.004539. eCollection 2018 Sep 1.
We propose a novel application of diffuse correlation spectroscopy to evaluate microvascular malfunctions of muscle tissue affected by hyperglycemia and determine their correlation with the severity of diabetic neuropathy at a later stage. Microvascular responses of the thigh muscle and the mechanical pain threshold of the hind paw of streptozotocin-induced type I diabetic rats were continuously monitored once per week for 70 days. Significantly decreased baseline blood flow and reactive hyperemia responses were observed as early as 1 week after hyperglycemia induction. The reactive hyperemia response at 2 weeks of hyperglycemia was highly correlated with the mechanical pain threshold at 8 weeks, at which time a decreased pain threshold was statistically confirmed in hyperglycemic rats relative to controls.
我们提出了一种漫散射相关光谱学的新应用，用于评估受高血糖影响的肌肉组织的微血管功能障碍，并确定其与后期糖尿病神经病变严重程度的相关性。对链脲佐菌素诱导的 I 型糖尿病大鼠的大腿肌肉微血管反应和后爪机械性疼痛阈值每周连续监测一次，共监测 70 天。早在高血糖诱导后 1 周就观察到基线血流和反应性充血反应显著降低。高血糖 2 周时的反应性充血反应与 8 周时的机械性疼痛阈值高度相关，此时高血糖大鼠的疼痛阈值相对于对照组在统计学上得到证实降低。
