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1例因双硫仑-乙醇反应导致显著ST段压低和心肌损伤的病例。

A case of marked ST depression and myocardial injury as a result of disulfiram-ethanol reaction.

作者信息

Shioji Keisuke, Izuhara Masayasu, Kadota Shin, Baba Osamu, Mitsuoka Hirokazu, Uegaito Takashi, Matsuda Mitsuo

机构信息

Department of Cardiovascular Medicine, Kishiwada City Hospital, 1001 Gakuhara-cho, Kishiwada City 596-8501, Japan.

出版信息

J Cardiol Cases. 2009 Dec 24;1(3):e137-e140. doi: 10.1016/j.jccase.2009.11.002. eCollection 2010 Jun.

DOI:10.1016/j.jccase.2009.11.002
PMID:30615756
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6264957/
Abstract

We report a case of a 50-year-old man with intractable hypotension, which led to ischemic electrocardiogram (ECG) changes and myocardial injury due to relative myocardial ischemia as a result of a disulfiram-ethanol reaction. This is the first report that assessed cardiac function during hypotension and ischemic ECG changes by emergency coronary angiography, left ventriculography, and right heart catheterization. This case indicates that disulfiram potentially has fatal side effects due to a disulfiram-ethanol reaction.

摘要

我们报告一例50岁男性患者，其出现顽固性低血压，因双硫仑-乙醇反应导致相对性心肌缺血，进而引发缺血性心电图（ECG）改变和心肌损伤。这是首例通过急诊冠状动脉造影、左心室造影和右心导管检查评估低血压期间心脏功能及缺血性ECG改变的报告。该病例表明，双硫仑因双硫仑-乙醇反应可能具有致命的副作用。

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本文引用的文献

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Acute myocardial infarction associated with disulfiram-alcohol interaction in a young man with normal coronary arteries.一名冠状动脉正常的年轻男性中与双硫仑-酒精相互作用相关的急性心肌梗死
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Chronic heart failure and micronutrients.慢性心力衰竭与微量营养素
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