College of Chemistry and Chemical Engineering, Henan Key Laboratory of Function-Oriented Porous Materials, Luoyang Normal University, Luoyang 471934, PR China.
College of Chemistry and Chemical Engineering, Henan Key Laboratory of Function-Oriented Porous Materials, Luoyang Normal University, Luoyang 471934, PR China.
Spectrochim Acta A Mol Biomol Spectrosc. 2019 Apr 5;212:88-93. doi: 10.1016/j.saa.2018.12.036. Epub 2018 Dec 21.
Bacillus anthracis spore causes anthrax to seriously threaten human health and even cause death. 2,6-Pyridinedicarboxylic acid (DPA) is a unique biomarker because it is a major component of Bacillus anthracis spore. Herein, we design europium functionalized silicon quantum dots as a ratiometric fluorescent nanoprobe to detect DPA with high sensitivity and selectivity. With the addition of DPA, the red emission peaks were observed at 618 nm. The novel probe enables ratiometric and sensitive DPA detection over nanomolar concentrations (as low as 1.02 μM). This work provided an efficient background-free and self-calibrating method for the recognition of DPA.
炭疽杆菌孢子会导致炭疽病，严重威胁人类健康，甚至致人死亡。2,6- 吡啶二甲酸（DPA）是一种独特的生物标志物，因为它是炭疽杆菌孢子的主要成分。在这里，我们设计了铕功能化硅量子点作为比率荧光纳米探针，以高灵敏度和选择性检测 DPA。随着 DPA 的加入，观察到 618nm 处的红色发射峰。新型探针能够在纳摩尔浓度（低至 1.02µM）下进行比率和灵敏的 DPA 检测。这项工作为 DPA 的识别提供了一种高效、无背景和自校准的方法。
