Department of Psychology and the Molecular & Behavioral Neuroscience Institute, University of Michigan, 205 Zina Pitcher Place, Ann Arbor, MI, 48109, USA.
Department of Psychiatry and Women's Health Research at Yale, Yale University School of Medicine, 135 College Street, Suite, New Haven, CT, 220, USA.
Biol Sex Differ. 2019 Jan 7;10(1):3. doi: 10.1186/s13293-018-0215-5.
The Fast-Track Action Committee on (the) Health Science and Technology Response to the Opioid Crisis recently released their draft report for public comment. This report provides the "roadmap" for a coordinated federal research and development response to the opioid crisis. Other than noting the important concerns regarding maternal and neonatal exposure to opioids, the report overlooks the laboratory, clinical, and epidemiological data that inform the need for further research on sex and gender differences in opioid addiction that have critical gender-based treatment and prevention implications. As we embark on research and development, investigations into the neurobiology of pain, opioid use, and addiction must include both females and males in model systems and, similarly, psychological and sociocultural investigations must study women and men. All data should be reported by sex and gender so that gender-specific treatment and prevention strategies derived from this research are provided to practitioners and the public. We encourage biomedical researchers and clinical care providers, as well as the public, to insist that a successful response to the opioid crisis should highlight the importance of understanding sex and gender differences in the current opioid epidemic.
快速行动委员会关于（医学）科学和技术应对阿片类药物危机的报告最近发布了草案供公众评议。该报告为协调联邦对阿片类药物危机的研发应对措施提供了“路线图”。除了注意到母婴接触阿片类药物的重要问题外，该报告忽略了实验室、临床和流行病学数据，这些数据表明需要进一步研究性别和性别差异对阿片类药物成瘾的影响，这对基于性别的治疗和预防具有重要意义。在我们开展研究和开发工作时，对疼痛、阿片类药物使用和成瘾的神经生物学的研究必须在模型系统中同时纳入女性和男性，同样，心理和社会文化研究也必须研究女性和男性。所有数据都应按性别报告，以便从这项研究中得出的针对特定性别的治疗和预防策略能够提供给从业者和公众。我们鼓励生物医学研究人员和临床护理提供者以及公众坚持认为，成功应对阿片类药物危机应强调了解当前阿片类药物流行中性别差异的重要性。
