Montcouquiol Mireille, Kelley Matthew W
INSERM, Neurocentre Magendie, U1215, F-33077 Bordeaux, France.
University of Bordeaux, Neurocentre Magendie, U1215, F-33077 Bordeaux, France.
Cold Spring Harb Perspect Med. 2020 Jan 2;10(1):a033266. doi: 10.1101/cshperspect.a033266.
Within the mammalian cochlea, sensory hair cells and supporting cells are aligned in curvilinear rows that extend along the length of the tonotopic axis. In addition, all of the cells within the epithelium are uniformly polarized across the orthogonal neural-abneural axis. Finally, each hair cell is intrinsically polarized as revealed by the presence of an asymmetrically shaped and apically localized stereociliary bundle. It has been known for some time that many of the developmental processes that regulate these patterning events are mediated, to some extent, by the core planar cell polarity (PCP) pathway. This article will review more recent work demonstrating how components of the PCP pathway interact with cytoskeletal motor proteins to regulate cochlear outgrowth. Finally, a signaling pathway originally identified for its role in asymmetric cell divisions has recently been shown to mediate several aspects of intrinsic hair cell polarity, including kinocilia migration, bundle shape, and elongation.
在哺乳动物的耳蜗中，感觉毛细胞和支持细胞呈曲线状排列，沿着音频拓扑轴的长度延伸。此外，上皮内的所有细胞在正交的神经-非神经轴上呈均匀极化。最后，每个毛细胞因其存在不对称形状且顶端定位的静纤毛束而具有内在极化。一段时间以来，人们已经知道，许多调节这些模式形成事件的发育过程在一定程度上是由核心平面细胞极性（PCP）途径介导的。本文将回顾最近的研究工作，展示PCP途径的组成部分如何与细胞骨架运动蛋白相互作用以调节耳蜗的生长。最后，一条最初因其在不对称细胞分裂中的作用而被鉴定的信号通路，最近已被证明可介导内在毛细胞极性的几个方面，包括动纤毛迁移、毛束形状和伸长。
