PDBj, Institute for Protein Research, Osaka University, Suita, Osaka, Japan.
Adv Exp Med Biol. 2018;1105:3-9. doi: 10.1007/978-981-13-2200-6_1.
By integrating the experimental information given from the Hybrid/ Integrative methods to determine the structures of large macromolecular machines, the static and dynamic molecular models in the atomic or semi-atomic resolution have been built with the aid of bioinformatics and computer simulations. Here, review of the recent progresses of such computational methods are made with discussion for the future direction.
通过整合杂交/综合方法提供的实验信息，来确定大型大分子机器的结构，借助生物信息学和计算机模拟，构建了具有原子或半原子分辨率的静态和动态分子模型。本文对这些计算方法的最新进展进行了综述，并讨论了未来的发展方向。
