St John's Institute of Dermatology, Guy's and St Thomas' NHS Trust, London, UK.
Dermatology Department, St Helier University Hospital, Carshalton, Surrey, UK.
Clin Exp Dermatol. 2019 Aug;44(6):651-653. doi: 10.1111/ced.13881. Epub 2019 Jan 7.
Vulval basal cell carcinomas (BCCs) are rare, representing < 5% of vulval malignancies and 1% of all BCCs. They often present with nonspecific symptoms and features that lead to large, poorly circumscribed and late-presenting lesions. Current and conventional treatments used to treat vulval BCC include cryotherapy, imiquimod and excision. However, recurrence rates as high as 20% have been reported with these treatments. Furthermore, there are no current clinical guidelines for their management. We present the first reported series of patients with vulval BCC treated with Mohs micrographic surgery (MMS). We report seven cases of vulval BCC treated with MMS at a tertiary referral centre over 3 years. Follow-up was performed at 3 months and up to 3 years. Our series demonstrates that there were no postoperative complications, functional sequelae or recurrences up to the 3-year follow-up. We therefore recommend that MMS should be considered in the management of vulval BCCs.
外阴基底细胞癌 (BCC) 较为罕见,占外阴恶性肿瘤的 <5%,占所有 BCC 的 1%。它们常表现为非特异性症状和特征,导致大而边界不清且晚期出现的病变。目前和传统的治疗外阴 BCC 的方法包括冷冻疗法、咪喹莫特和切除术。然而,这些治疗方法的复发率高达 20%。此外,目前尚无针对其治疗的临床指南。我们报告了首例采用 Mohs 显微外科手术 (MMS) 治疗的外阴 BCC 患者系列。我们报告了在 3 年时间里,一家三级转诊中心采用 MMS 治疗的 7 例外阴 BCC 病例。随访时间为 3 个月至 3 年。我们的系列研究表明,在 3 年的随访期间,没有出现术后并发症、功能后遗症或复发。因此,我们建议应考虑采用 MMS 治疗外阴 BCC。