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经Mohs 显微外科手术治疗眼周基底细胞癌的管理。

Management of periocular basal cell carcinoma by Mohs micrographic surgery.

机构信息

Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, England.

出版信息

J Dermatolog Treat. 2013 Jun;24(3):232-4. doi: 10.3109/09546634.2012.690506. Epub 2012 Jul 10.

Abstract

BACKGROUND/AIMS: To determine the success of Mohs micrographic surgery (MMS) for periocular basal cell carcinoma (BCC) at a tertiary referral centre in the UK.

DESIGN

A retrospective interventional case series covering 5 years of practice.

METHODS

Review of medical records of 104 consecutive patients who underwent MMS for confirmed periocular BCC. The main outcome measure was biopsy-proven recurrence of BCC at the same anatomical location after MMS. Secondary outcome measures included tumour site, histological subtype and length of follow-up.

RESULTS

104 patients underwent MMS for periocular BCC from January 2003 to July 2008. 63 (62%) of the surgeries were for primary BCC and 25 procedures (25%) were for recurrent or residual BCC. 64% of tumours were nodular BCC. The mean follow-up was 28 months (range 1-85 months). Six recurrences were identified in total. The recurrence rate following MMS for primary BCC was 1.6% (1 patient) compared to 20% (5 patients) in the patient group treated for residual or recurrent tumours. The mean time to recurrence was 39 months (range 16-71 months).

CONCLUSIONS

MMS for primary BCC has a very high success rate but the recurrence rate increases significantly in cases of recurrent or residual tumours.

摘要

背景/目的:在英国的一家三级转诊中心确定 Mohs 显微外科手术(MMS)治疗眼周基底细胞癌(BCC)的成功率。

设计

一项涵盖 5 年实践的回顾性干预性病例系列研究。

方法

回顾性分析了 104 例连续接受 MMS 治疗的确诊为眼周 BCC 的患者的病历。主要观察指标是 MMS 治疗后同一解剖部位 BCC 的活检证实复发率。次要观察指标包括肿瘤部位、组织学亚型和随访时间。

结果

2003 年 1 月至 2008 年 7 月期间,104 例患者因眼周 BCC 接受 MMS 治疗。63 例(62%)手术为原发性 BCC,25 例(25%)为复发性或残留 BCC。64%的肿瘤为结节状 BCC。平均随访时间为 28 个月(范围 1-85 个月)。共发现 6 例复发。MMS 治疗原发性 BCC 的复发率为 1.6%(1 例患者),而治疗复发性或残留肿瘤的患者组复发率为 20%(5 例患者)。复发的平均时间为 39 个月(范围 16-71 个月)。

结论

MMS 治疗原发性 BCC 的成功率非常高,但在复发性或残留肿瘤的情况下,复发率显著增加。

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