测量孕妇孕前人体测量学和新生儿 DNA 甲基化。
Measured maternal prepregnancy anthropometry and newborn DNA methylation.
机构信息
Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health & Human Development, 6710B Rockledge Drive 7004, Bethesda, MD 20817, USA.
Division of Biostatistics, School of Public Health, University of Minnesota, A460 Mayo Building, MMC 303, 420 Delaware St SE, Minneapolis, MN 55455, USA.
出版信息
Epigenomics. 2019 Feb;11(2):187-198. doi: 10.2217/epi-2018-0099. Epub 2019 Jan 8.
Abstract
AIM
We examined maternal prepregnancy anthropometry and cord blood DNA methylation.
METHODS
Associations between maternal measures (i.e., weight, height, waist circumference, hip circumference, skinfolds, leptin) and methylation β-values at each CpG (measured by the Infinium MethylationEPIC BeadChip) were estimated among 391 singletons.
RESULTS
Total of 18% of mothers were obese (body mass index ≥ 30) and 27% centrally obese (waist-to-hip ratio ≥ 0.85). One Bonferroni significant CpG with respect to obesity (cg02975187) and two with central obesity (cg12053563, cg12549355) were identified (p < 6 × 10). A suggestive association (p < 10) was observed at SFRS8 with increasing body mass index. SFRS8 was previously identified with propensity for weight gain in adults.
CONCLUSION
While associations identified with multiple measures related to maternal adiposity suggest different pathways, methylation differences were small in magnitude.
摘要
目的
我们研究了母体孕前人体测量学和脐带血 DNA 甲基化。
方法
在 391 名单胎中，我们评估了母体指标（即体重、身高、腰围、臀围、皮褶厚度、瘦素）与每个 CpG 的甲基化 β 值（通过 Infinium MethylationEPIC BeadChip 测量）之间的关联。
结果
共有 18%的母亲肥胖（体重指数≥30），27%的母亲中心性肥胖（腰臀比≥0.85）。有一个 CpG 与肥胖相关（cg02975187），两个与中心性肥胖相关（cg12053563，cg12549355），达到 Bonferroni 显著性水平（p<6×10）。SFRS8 与体重指数的增加呈显著相关（p<10）。SFRS8 先前被鉴定为与成年人体重增加的倾向有关。
结论
尽管与母体肥胖相关的多个指标的关联提示了不同的途径，但甲基化差异的幅度较小。
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