Omma Ahmet, Sandikci Sevinc Can, Colak Seda, Tecer Duygu, Yucel Cigdem, Ozbalkan Zeynep
Department of Rheumatology, Ankara Numune Training and Research Hospital, Ankara, Turkey.
Department of Rheumatology, Şanlıurfa Mehmet Akif İnan Training and Research Hospital, Şanlıurfa, Turkey.
Postepy Dermatol Alergol. 2018 Dec;35(6):609-613. doi: 10.5114/pdia.2017.71269. Epub 2018 Nov 13.
Behçet's disease (BD) is a complex multisystemic inflammatory disorder which is characterized by recurrent attacks of acute inflammation. As there is no universally recognized pathognomonic laboratory marker of BD, its diagnosis is still based on clinical findings.
To evaluate the role of calprotectin and ischemia modified albumin (IMA) as biomarkers in the assessment of disease activity of BD.
A total of 93 patients with BD and 62 age- and gender-matched healthy controls were included in the study. Disease activity was assessed with the BD Current Activity Form (BDCAF) score. Serum levels of calprotectin, high-sensitivity C-reactive protein (hsCRP) and IMA were measured in the patient and control groups.
Serum levels of calprotectin, IMA and hsCRP in patients with BD were higher than those of the healthy control group ( < 0.001 for all). No correlations between calprotectin and IMA, hsCRP, erythrocyte sedimentation rate, CRP, or BDCAF score were found.
As the calprotectin level are increased in BD patients, it could be a candidate biomarker which plays a role in BD pathogenesis.
白塞病（BD）是一种复杂的多系统炎症性疾病，其特征为急性炎症反复发作。由于尚无普遍认可的白塞病特异性实验室标志物，其诊断仍基于临床发现。
评估钙卫蛋白和缺血修饰白蛋白（IMA）作为生物标志物在评估白塞病疾病活动度中的作用。
本研究共纳入93例白塞病患者和62例年龄及性别匹配的健康对照。采用白塞病当前活动度表（BDCAF）评分评估疾病活动度。测定患者组和对照组血清钙卫蛋白、高敏C反应蛋白（hsCRP）和IMA水平。
白塞病患者血清钙卫蛋白、IMA和hsCRP水平高于健康对照组（均P<0.001）。未发现钙卫蛋白与IMA、hsCRP、红细胞沉降率、CRP或BDCAF评分之间存在相关性。
由于白塞病患者钙卫蛋白水平升高，它可能是在白塞病发病机制中起作用的候选生物标志物。
