Lee Seung Bum, Kim Hyun-Ki, Park Sang Hyuk, Lim Ji-Hun, Park Sang Hyoung
Department of Gastroenterology Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea.
Department of Laboratory Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea.
Intest Res. 2024 Jan;22(1):75-81. doi: 10.5217/ir.2023.00065. Epub 2023 Nov 1.
BACKGROUND/AIMS: The achievement of endoscopic remission is an important therapeutic goal in the treatment of inflammatory bowel diseases (IBD). We aimed to evaluate the role of fecal calprotectin (FCP) and ischemia-modified albumin (IMA) as biomarkers for evaluating IBD disease activity.
A total of 48 patients with IBD (20 with ulcerative colitis and 28 with Crohn's disease) were included in this study. FCP and serum C-reactive protein levels, erythrocyte sedimentation rate, and IMA were measured in patients with IBD and compared with endoscopic findings.
Elevated FCP and serum IMA levels were significantly associated with endoscopic non-mucosal healing. The correlation between FCP and IMA was not significant. Analysis of the receiver operating characteristic curve showed that both FCP and IMA had diagnostic value in predicting non-mucosal healing. When the Ln(FCP)+IMA/10 value was calculated using both factors, the predictive value for non-mucosal healing increased; however, no significant difference was observed.
IMA could be a candidate serum biomarker for predicting endoscopic mucosal healing in IBD.
背景/目的：实现内镜缓解是炎症性肠病（IBD）治疗的重要目标。我们旨在评估粪便钙卫蛋白（FCP）和缺血修饰白蛋白（IMA）作为评估IBD疾病活动生物标志物的作用。
本研究共纳入48例IBD患者（20例溃疡性结肠炎患者和28例克罗恩病患者）。检测IBD患者的FCP、血清C反应蛋白水平、红细胞沉降率和IMA，并与内镜检查结果进行比较。
FCP和血清IMA水平升高与内镜下黏膜未愈合显著相关。FCP与IMA之间的相关性不显著。受试者工作特征曲线分析表明，FCP和IMA在预测黏膜未愈合方面均具有诊断价值。当使用这两个因素计算Ln（FCP）+IMA/10值时，黏膜未愈合的预测价值增加；然而，未观察到显著差异。
IMA可能是预测IBD内镜下黏膜愈合的候选血清生物标志物。
