Rheumatology and Rehabilitation Department, Faculty of Medicine, Zagazig University, Egypt.
Rheumatology and Rehabilitation Department, Faculty of Medicine, Zagazig University, Egypt; Physical Medicine and Rehabilitation Department, Security Forces Hospital, Makkah, Saudi Arabia.
Reumatol Clin (Engl Ed). 2023 Apr;19(4):188-196. doi: 10.1016/j.reumae.2023.03.005.
Behcet's disease (BD) is an autoimmune systemic inflammatory disease, and its exact pathogenesis is unknown. There are currently no specific tests to evaluate the disease activity of BD, making its management more difficult. This study aims to determine the neutrophil/albumin ratio (NAR) and C-reactive protein (CRP) to albumin ratio (CAR) and investigate their associations with clinical findings in patients with BD and to determine optimum cutoff levels of CAR and NAR.
The study included 75 consecutively recruited patients with BD with a mean age of 33.29±6.23 years and disease duration of 7.21±4.64 years, as well as 75 healthy participants. Clinical characteristics and laboratory data were obtained. Disease activity was assessed using the BD current activity form score (BDCAF).
NAR and CAR were elevated in patients with BD compared with those of healthy controls (NAR: 1.08±0.34 vs. 0.607±0.06, CAR: 2.49±1.73 vs. 0.39±0.142; p<0.0001), as well as in active BD versus inactive BD. Both NAR and CAR were significantly correlated with CRP, active uveitis, and BDCAF score (p≤0.05). In patients with active BD, the cutoff value of NAR was >0.9744 (sensitivity: 89.74%, specificity: 80.56%), while that of CAR was >2.04 (sensitivity: 74.36%, specificity: 83.33%).
NAR and CAR are both elevated in patients with BD and may contribute to its active state. NAR and CAR can be feasible and inexpensive markers for predicting BD activity.
贝赫切特病（BD）是一种自身免疫性系统性炎症性疾病，其确切发病机制尚不清楚。目前尚无专门的测试来评估 BD 的疾病活动度，这使得其治疗更加困难。本研究旨在确定中性粒细胞/白蛋白比值（NAR）和 C 反应蛋白（CRP）与白蛋白比值（CAR），并探讨其与 BD 患者临床发现的关系，确定 CAR 和 NAR 的最佳临界值。
本研究纳入了 75 例连续招募的 BD 患者，平均年龄为 33.29±6.23 岁，病程为 7.21±4.64 年，以及 75 名健康对照者。获得了临床特征和实验室数据。使用 BD 当前活动评分（BDCAF）评估疾病活动度。
与健康对照组相比，BD 患者的 NAR 和 CAR 升高（NAR：1.08±0.34 对 0.607±0.06，CAR：2.49±1.73 对 0.39±0.142；p<0.0001），活动期 BD 患者高于非活动期 BD 患者。NAR 和 CAR 均与 CRP、活动性葡萄膜炎和 BDCAF 评分显著相关（p≤0.05）。在活动期 BD 患者中，NAR 的临界值>0.9744（敏感性：89.74%，特异性：80.56%），CAR 的临界值>2.04（敏感性：74.36%，特异性：83.33%）。
BD 患者的 NAR 和 CAR 均升高，可能与疾病的活动状态有关。NAR 和 CAR 可能是预测 BD 活动的可行且廉价的标志物。
