Bachiller Sara, Jiménez-Ferrer Itzia, Paulus Agnes, Yang Yiyi, Swanberg Maria, Deierborg Tomas, Boza-Serrano Antonio
Experimental Neuroinflammation Laboratory, Lund University, Lund, Sweden.
Translational Neurogenetics Unit, Wallenberg Neuroscience Center, Lund University, Lund, Sweden.
Front Cell Neurosci. 2018 Dec 18;12:488. doi: 10.3389/fncel.2018.00488. eCollection 2018.
Microglia represent a specialized population of macrophages-like cells in the central nervous system (CNS) considered immune sentinels that are capable of orchestrating a potent inflammatory response. Microglia are also involved in synaptic organization, trophic neuronal support during development, phagocytosis of apoptotic cells in the developing brain, myelin turnover, control of neuronal excitability, phagocytic debris removal as well as brain protection and repair. Microglial response is pathology dependent and affects to immune, metabolic. In this review, we will shed light on microglial activation depending on the disease context and the influence of factors such as aging, environment or cell-to-cell interaction.
小胶质细胞是中枢神经系统（CNS）中一类特殊的巨噬细胞样细胞，被认为是免疫哨兵，能够协调强大的炎症反应。小胶质细胞还参与突触组织、发育过程中的神经元营养支持、发育中大脑凋亡细胞的吞噬、髓鞘更新、神经元兴奋性控制、吞噬碎片清除以及脑保护和修复。小胶质细胞反应取决于病理状态，并影响免疫和代谢。在本综述中，我们将根据疾病背景以及衰老、环境或细胞间相互作用等因素的影响，阐明小胶质细胞的激活情况。
