Fan Jie, Gan Jun, Liu Wanting, Zhong Mingtian, Liao Haiyan, Zhang Hongchun, Yi Jinyao, Chan Raymond C K, Tan Changlian, Zhu Xiongzhao
Medical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, China.
Medical Psychological Institute of Central South University, Changsha, China.
Front Behav Neurosci. 2018 Dec 19;12:319. doi: 10.3389/fnbeh.2018.00319. eCollection 2018.
Previous studies have indicated the resting-state default mode network (DMN) related connectivity serving as predictor of sustained attention performance in healthy people. Interestingly, sustained attention deficits as well as DMN-involved functional connectivity (FC) alterations are common in both patients with schizophrenia (SCZ) and with obsessive-compulsive disorder (OCD). Thus, the present study was designed to investigate whether the DMN related resting-state connectivity alterations in these two psychiatric disorders were neural correlates of their sustained attention impairments. The study included 17 SCZ patients, 35 OCD patients and 36 healthy controls (HCs). Sustained attention to response task was adopted to assess the sustained attention. Resting-state scan was administrated and seed-based whole-brain FC analyses were performed with seeds located in classical DMN regions including bilateral medial prefrontal cortex (mPFC) and posterior cingulate cortex (PCC). Both SCZ and OCD patients had poorer sustained attention than HCs. Sustained attention deficits in OCD was negatively correlated with their impaired FC of right mPFC-left superior frontal gyrus (SFG) within DMN, and that in SCZ was significantly correlated with their altered FC of left mPFC-bilateral anterior cingulate cortex (ACC) which indicated interaction between DMN and salience network. In addition, the FC between left mPFC and right parietal lobe indicating the interaction between DMN and frontal-parietal network was correlated with sustained attention in both SCZ and OCD. These findings suggest the importance of DMN-involved connectivity, both within and between networks in underlying sustained attention deficits in OCD and SCZ. Results further support the potential of resting-state FC in complementing information for cognitive deficits in psychiatric disorders.
先前的研究表明，静息态默认模式网络（DMN）相关的连通性可作为健康人持续注意力表现的预测指标。有趣的是，精神分裂症（SCZ）患者和强迫症（OCD）患者均存在持续注意力缺陷以及涉及DMN的功能连通性（FC）改变。因此，本研究旨在调查这两种精神疾病中与DMN相关的静息态连通性改变是否是其持续注意力受损的神经相关因素。该研究纳入了17名SCZ患者、35名OCD患者和36名健康对照者（HCs）。采用持续注意力反应任务来评估持续注意力。进行静息态扫描，并对位于经典DMN区域（包括双侧内侧前额叶皮质（mPFC）和后扣带回皮质（PCC））的种子进行基于种子的全脑FC分析。SCZ患者和OCD患者的持续注意力均比HCs差。OCD患者的持续注意力缺陷与其DMN内右侧mPFC-左侧额上回（SFG）的FC受损呈负相关，而SCZ患者的持续注意力缺陷与其左侧mPFC-双侧前扣带回皮质（ACC）的FC改变显著相关，这表明DMN与突显网络之间存在相互作用。此外，左侧mPFC与右侧顶叶之间的FC表明DMN与额顶叶网络之间的相互作用，在SCZ和OCD患者中均与持续注意力相关。这些发现表明，DMN相关的连通性在OCD和SCZ患者潜在的持续注意力缺陷中，无论是在网络内部还是网络之间都具有重要意义。结果进一步支持了静息态FC在补充精神疾病认知缺陷信息方面的潜力。
