Department of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, 410011, China.
Division of Molecular Imaging and Neuropathology, New York State Psychiatric Institute and Departments of Psychiatry and Radiology, Columbia University, New York, NY, 10032, USA.
Neurosci Bull. 2017 Feb;33(1):73-84. doi: 10.1007/s12264-016-0090-1. Epub 2016 Dec 19.
Schizophrenia is a severe mental disorder characterized by impaired perception, delusions, thought disorder, abnormal emotion regulation, altered motor function, and impaired drive. The default mode network (DMN), since it was first proposed in 2001, has become a central research theme in neuropsychiatric disorders, including schizophrenia. In this review, first we define the DMN and describe its functional activity, functional and anatomical connectivity, heritability, and inverse correlation with the task positive network. Second, we review empirical studies of the anatomical and functional DMN, and anti-correlation between DMN and the task positive network in schizophrenia. Finally, we review preliminary evidence about the relationship between antipsychotic medications and regulation of the DMN, review the role of DMN as a treatment biomarker for this disease, and consider the DMN effects of individualized therapies for schizophrenia.
精神分裂症是一种严重的精神障碍，其特征是感知障碍、妄想、思维障碍、情绪调节异常、运动功能改变和驱动力受损。默认模式网络（DMN）自 2001 年首次提出以来，已成为神经精神疾病（包括精神分裂症）的一个核心研究主题。在这篇综述中，我们首先定义了 DMN，并描述了其功能活动、功能和解剖连接、遗传性以及与任务正网络的负相关关系。其次，我们回顾了精神分裂症中 DMN 的解剖和功能的实证研究，以及 DMN 与任务正网络之间的负相关关系。最后，我们回顾了抗精神病药物与 DMN 调节之间关系的初步证据，综述了 DMN 作为这种疾病治疗生物标志物的作用，并考虑了精神分裂症个体化治疗的 DMN 效应。
