von Wolff Michael, Fäh Monika, Roumet Marie, Mitter Vera, Stute Petra, Griesinger Georg, Kohl Schwartz Alexandra
Division of Gynaecological Endocrinology and Reproductive Medicine, University Women's Hospital, Inselspital University Hospital, Bern, Switzerland.
CTU Bern, Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.
Front Endocrinol (Lausanne). 2018 Dec 20;9:776. doi: 10.3389/fendo.2018.00776. eCollection 2018.
Does the endometrial thickness (EMT) at the time of follicle aspiration correlate with the pregnancy rate in unstimulated menstrual cycles? This is a retrospective, observational single center study.105 women with regular menstrual cycles undergoing their first NC-IVF cycle with an embryo transfer were analyzed. Clinical pregnancy and live birth rates were calculated and data were adjusted for women's age, cycle day of follicle aspiration and body mass index (BMI). Age of participants was 35.0 y [32.0; 37.0]. Follicle aspiration was performed on day 14.0 [12.0; 15.0] of the cycle. Total clinical pregnancy rate was 24.8% and live birth rate 15.2% per transfer. Pregnancy rate in women with endometrial thickness ≤7 mm ( = 27) was 7.4 and 30.8% in women >7 mm ( = 78) (OR 5.56, 1.22-25.36) ( = 0.03). Live birth rates were not significantly different. Quadratic regression analysis revealed lower pregnancy rates in women with thin (around <8 mm) as well as with thick (around >11 mm) endometria. -value after crude quadratic analysis was 0.028 and after adjustment for age, day of aspiration and BMI was 0.039. Significance was not reached for live birth rates. Thin endometrium should also be considered as an independent negative prognostic factor for achieving pregnancy in women without ovarian stimulation.
卵泡抽吸时的子宫内膜厚度（EMT）与未刺激月经周期中的妊娠率相关吗？这是一项回顾性、观察性单中心研究。分析了105名月经周期规律且正在进行首次非控制性体外受精（NC-IVF）周期并进行胚胎移植的女性。计算了临床妊娠率和活产率，并对女性年龄、卵泡抽吸的周期日和体重指数（BMI）进行了数据调整。参与者年龄为35.0岁[32.0；37.0]。在周期的第14.0天[12.0；15.0]进行卵泡抽吸。每次移植的总临床妊娠率为24.8%，活产率为15.2%。子宫内膜厚度≤7mm的女性（n = 27）的妊娠率为7.4%，>7mm的女性（n = 78）为30.8%（OR 5.56，1.22 - 25.36）（P = 0.03）。活产率无显著差异。二次回归分析显示，子宫内膜薄（约<8mm）以及厚（约>11mm）的女性妊娠率较低。粗二次分析后的P值为0.028，在调整年龄、抽吸日和BMI后为0.039。活产率未达到显著性。子宫内膜薄也应被视为未接受卵巢刺激的女性实现妊娠的独立负面预后因素。
