Campos José Miguel, Sousa Ana Catarina, Pinto Pedro Olivério, Ribeiro Jorge, França Miguel Lacueva, Caseiro Ana Rita, Branquinho Mariana Vieira, Pedrosa Sílvia Santos, Mendonça Carla, Brandão Ana, Santos José Domingos, Afonso Américo, Atayde Luís Miguel, Luís Ana Lúcia, Maurício Ana Colette
1Escola Universitária Vasco da Gama (EUVG), Hospital Veterinário Universitário de Coimbra, Coimbra, Portugal.
2Departamento de Clínicas Veterinárias, Instituto de Ciências Biomédicas de Abel Salazar (ICBAS), Universidade do Porto (UP), Rua de Jorge Viterbo Ferreira, n° 228, 4050-313 Porto, Portugal.
Biomater Res. 2018 Dec 29;22:38. doi: 10.1186/s40824-018-0150-x. eCollection 2018.
Autologous bone remains the gold standard grafting substrate for bone fusions used for small gaps and critical defects. However, significant morbidity is associated with the harvesting of autologous bone grafts and, for that reason, alternative bone graft substitutes have been developed. In the present case series, a glass-reinforced hydroxyapatite synthetic bone substitute, with osteoinductive and osteoconductive proprieties, was applied. This synthetic bone substitute comprises the incorporation of PO-CaO glass-based system within a hydroxyapatite matrix, moulded into spherical pellets with 250-500 μm of diameter. A total of 14 veterinary clinical cases of appendicular bone defects and maxillary / mandibular bone defects are described. In all clinical cases, the synthetic bone substitute was used to fill bone defects, enhancing bone regeneration and complementing the recommended surgical techniques. Results demonstrated that it is an appropriate synthetic bone graft available to be used in veterinary patients. It functioned as a space filler in association with standard orthopaedic and odontological procedures of stabilization, promoting a faster bone fusion without any local or systemic adverse reactions. This procedure improves the animals' quality of life, decreasing pain and post-operative recovery period, as well as increasing bone stability improving positive clinical outcomes.
自体骨仍然是用于小间隙和关键缺损骨融合的金标准移植基质。然而，自体骨移植的采集会带来显著的发病率，因此，人们开发了替代骨移植替代品。在本病例系列中，应用了一种具有骨诱导和骨传导特性的玻璃增强羟基磷灰石合成骨替代品。这种合成骨替代品包括将基于PO-CaO玻璃的系统掺入羟基磷灰石基质中，模制成直径为250-500μm的球形颗粒。共描述了14例四肢骨缺损和上颌/下颌骨缺损的兽医临床病例。在所有临床病例中，合成骨替代品被用于填充骨缺损，促进骨再生并补充推荐的手术技术。结果表明，它是一种适用于兽医患者的合成骨移植材料。它与标准的骨科和牙科稳定手术联合用作空间填充物，促进更快的骨融合，且无任何局部或全身不良反应。该手术改善了动物的生活质量，减轻了疼痛，缩短了术后恢复期，增强了骨稳定性，改善了临床效果。
